The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter

被引：40
作者：
Satrialdi [1 ,2 ]
Munechika, Reina [1 ]
Biju, Vasudevanpillai [3 ,4 ]
Takano, Yuta [3 ,4 ]
Harashima, Hideyoshi [1 ]
Yamada, Yuma [1 ]
机构：
[1] Hokkaido Univ, Fac Pharmaceut Sci, Kita Ku, Kita 12,Nishi 6, Sapporo, Hokkaido 0600812, Japan
[2] Inst Teknol Bandung, Sch Pharm, Ganesha 10, Bandung 40132, Indonesia
[3] Hokkaido Univ, Res Inst Elect Sci, Kita Ku, Kita 20 Nishi 10, Sapporo, Hokkaido 0010020, Japan
[4] Hokkaido Univ, Grad Sch Environm Sci, Kita Ku, Kita 10 Nishi 5, Sapporo, Hokkaido 0600810, Japan
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 07期
关键词：
MITOCHONDRIAL DELIVERY; CELLS; MACROMOLECULE; ACTIVATION; MECHANISMS; APOPTOSIS;
D O I：
10.1039/c9cc08563g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The uncontrolled production of reactive oxygen species during photodynamic therapy (PDT) induces oxidative stress. The full potential of PDT is accomplished by delivery of a pi-extended porphyrin-type photosensitizer into mitochondria of tumor cells using a MITO-Porter, a mitochondrial targeting nanodevice. This strategy can be implemented for innovative cancer therapy.
引用
收藏
页码：1145 / 1148
页数：4
相关论文
共 28 条
  • [1] Cardiac progenitor cells activated by mitochondrial delivery of resveratrol enhance the survival of a doxorubicin-induced cardiomyopathy mouse model via the mitochondrial activation of a damaged myocardium
    Abe, Jiro
    Yamada, Yuma
    Takeda, Atsuhito
    Harashima, Hideyoshi
    [J]. JOURNAL OF CONTROLLED RELEASE, 2018, 269 : 177 - 188
  • [2] Mitochondrial superoxide: Production, biological effects, and activation of uncoupling proteins
    Brand, MD
    Affourtit, C
    Esteves, TC
    Green, K
    Lambert, AJ
    Miwa, S
    Pakay, JL
    Parker, N
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (06) : 755 - 767
  • [3] Mitochondria-targeted Triphenylamine Derivatives Activatable by Two-Photon Excitation for Triggering and Imaging Cell Apoptosis
    Chennoufi, Rahima
    Bougherara, Houcine
    Gagey-Eilstein, Nathalie
    Dumat, Blaise
    Henry, Etienne
    Subra, Frederic
    Bury-Mone, Stephanie
    Mahuteau-Betzer, Florence
    Tauc, Patrick
    Teulade-Fichou, Marie-Paule
    Deprez, Eric
    [J]. SCIENTIFIC REPORTS, 2016, 6
  • [4] Photodynamic therapy for cancer
    Dolmans, DEJGJ
    Fukumura, D
    Jain, RK
    [J]. NATURE REVIEWS CANCER, 2003, 3 (05) : 380 - 387
  • [5] Characterization of Photofrin photobleaching for singlet oxygen dose estimation during photodynamic therapy of MLL cells in vitro
    Dysart, JS
    Patterson, MS
    [J]. PHYSICS IN MEDICINE AND BIOLOGY, 2005, 50 (11) : 2597 - 2616
  • [6] NIR dyes for bioimaging applications
    Escobedo, Jorge O.
    Rusin, Oleksandr
    Lim, Soojin
    Strongin, Robert M.
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2010, 14 (01) : 64 - 70
  • [7] THE ROLE OF DIOLEOYL PHOSPHATIDYLETHANOLAMINE IN CATIONIC LIPOSOME-MEDIATED GENE-TRANSFER
    FARHOOD, H
    SERBINA, N
    HUANG, L
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1995, 1235 (02): : 289 - 295
  • [8] Mitochondrial transgene expression via an artificial mitochondrial DNA vector in cells from a patient with a mitochondrial disease
    Ishikawa, Takuya
    Somiya, Kana
    Munechika, Reina
    Harashima, Hideyoshi
    Yamada, Yuma
    [J]. JOURNAL OF CONTROLLED RELEASE, 2018, 274 : 109 - 117
  • [9] INITIATION OF AUTOPHAGY BY PHOTODYNAMIC THERAPY
    Kessel, David
    Oteinick, Nancy L.
    [J]. METHODS IN ENZYMOLOGY VOL 453: AUTOPHAGY IN DISEASE AND CLINICAL APPLICATIONS, PT C, 2009, 453 : 1 - 16
  • [10] High resolution imaging of intracellular oxygen concentration by phosphorescence lifetime
    Kurokawa, Hiromi
    Ito, Hidehiro
    Inoue, Mai
    Tabata, Kenji
    Sato, Yoshifumi
    Yamagata, Kazuya
    Kizaka-Kondoh, Shinae
    Kadonosono, Tetsuya
    Yano, Shigenobu
    Inoue, Masahiro
    Kamachi, Toshiaki
    [J]. SCIENTIFIC REPORTS, 2015, 5
123