The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients

被引：11

作者：

Liu, Jin ^{[1
]}

Bian, Lingling ^{[1
]}

Ji, Li ^{[1
]}

Chen, Yang ^{[1
]}

Chen, Heng ^{[1
]}

Gu, Yong ^{[1
]}

Ma, Bingqin ^{[1
]}

Gu, Wei ^{[10
]}

Xu, Xinyu ^{[1
]}

Shi, Yun ^{[1
]}

Wang, Jian ^{[6
]}

Zhu, Dalong ^{[7
]}

Sun, Zilin ^{[8
]}

Ma, Jianhua ^{[9
]}

Jin, Hui ^{[8
]}

Shi, Xing ^{[10
]}

Miao, Heng ^{[11
]}

Xin, Bing ^{[12
]}

Zhu, Yan ^{[13
]}

Zhang, Zhenwen ^{[13
]}

Bu, Ruifang ^{[14
]}

Xu, Lan ^{[14
]}

Shi, Guangde ^{[15
]}

Tang, Wei ^{[15
]}

Li, Wei ^{[16
]}

Zhou, Dongmei ^{[16
]}

Liang, Jun ^{[17
]}

Cheng, Xingbo ^{[18
]}

Shi, Bimin ^{[18
]}

Dong, Jixiang ^{[19
]}

Hu, Ji ^{[19
]}

Fang, Chen ^{[19
]}

Zhong, Shao ^{[20
]}

Yu, Weinan ^{[21
]}

Lu, Weiping ^{[22
]}

Wu, Chenguang ^{[23
]}

Qian, Li ^{[23
]}

Yu, Jiancheng ^{[24
]}

Gao, Jialin ^{[25
]}

Fei, Xiaoqiang ^{[25
]}

Zhang, Qingqing ^{[25
]}

Wang, Xueqin ^{[26
]}

Cui, Shiwei ^{[27
]}

Cheng, Jinluo ^{[28
]}

Xu, Ning ^{[29
]}

Wang, Guofeng ^{[29
]}

Han, Guoqing ^{[30
]}

Xu, Chunrong ^{[31
]}

Xie, Yun ^{[32
]}

An, Minmin ^{[33
]}

机构：

[1] Nanjing Med Univ, Dept Endocrinol & Metab, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China

[2] Univ Colorado Denver, Barbara Davis Ctr Childhood Diabet, Aurora, CO 80045 USA

[3] Nanjing Med Univ, Key Lab Human Funct Genom Jiangsu Prov, Nanjing 210000, Jiangsu, Peoples R China

[4] Nanjing Med Univ, Dept Isotop Lab, Nanjing 210000, Jiangsu, Peoples R China

[5] Jiangsu Prov Peoples Hosp, HLA Lab, Nanjing 210029, Jiangsu, Peoples R China

[6] Nanjing Mil Command, Dept Endocrinol & Metab, Nanjing Gen Hosp, Nanjing 210002, Jiangsu, Peoples R China

[7] Nanjing Univ, Dept Endocrinol & Metab, Nanjing Drum Tower Hosp, Affiliated Hosp,Med Sch, Nanjing 210008, Jiangsu, Peoples R China

[8] Southeast Univ, Dept Endocrinol & Metab, Zhongda Hosp, Nanjing 210009, Jiangsu, Peoples R China

[9] Nanjing First Hosp, Dept Endocrinol & Metab, Nanjing 210000, Jiangsu, Peoples R China

[10] Nanjing Childrens Hosp, Dept Endocrinol & Metab, Nanjing 210008, Jiangsu, Peoples R China

[11] Nanjing Med Univ, Dept Endocrinol & Metab, Affiliated Hosp 2, Nanjing 210011, Jiangsu, Peoples R China

[12] Nanjing Govt Hosp, Dept Endocrinol & Metab, Nanjing 210008, Jiangsu, Peoples R China

[13] Northern Jiangsu Peoples Hosp, Dept Endocrinol & Metab, Yangzhou 225001, Jiangsu, Peoples R China

[14] Wuxi Peoples Hosp, Dept Endocrinol & Metab, Wuxi 214023, Peoples R China

[15] Jiangsu Jiangyin Peoples Hosp, Dept Endocrinol & Metab, Wuxi 214400, Peoples R China

[16] Xuzhou Med Coll, Dept Endocrinol & Metab, Affiliated Hosp, Xuzhou 221006, Peoples R China

[17] Xuzhou Cent Hosp, Dept Endocrinol & Metab, Xuzhou 221009, Peoples R China

[18] Soochow Univ, Dept Endocrinol & Metab, Affiliated Hosp 1, Suzhou 215006, Peoples R China

[19] Soochow Univ, Dept Endocrinol & Metab, Affiliated Hosp 2, Suzhou 215004, Peoples R China

[20] First Peoples Hosp Kunshan, Dept Endocrinol & Metab, Suzhou 215300, Peoples R China

[21] Huaian Second Peoples Hosp, Dept Endocrinol & Metab, Huaian 223002, Peoples R China

[22] Huaian First Peoples Hosp, Dept Endocrinol & Metab, Huaian 223300, Peoples R China

[23] First Peoples Hosp Zhenjiang, Dept Endocrinol & Metab, Zhenjiang 212002, Peoples R China

[24] Yancheng City 1 Peoples Hosp, Dept Endocrinol & Metab, Yancheng 224005, Peoples R China

[25] Jiangsu Taizhou Peoples Hosp, Dept Endocrinol & Metab, Taizhou 225300, Peoples R China

[26] First Peoples Hosp Nantong, Dept Endocrinol & Metab, Nantong 226000, Peoples R China

[27] Nantong Univ, Dept Endocrinol & Metab, Affiliated Hosp, Nantong 226001, Peoples R China

[28] Changzhou 2 Peoples Hosp, Dept Endocrinol & Metab, Changzhou 213003, Peoples R China

[29] First Peoples Hosp Lianyungang, Dept Endocrinol & Metab, Lianyungang 222002, Peoples R China

[30] Binhai Peoples Hosp Yancheng City, Dept Endocrinol & Metab, Yancheng 224500, Peoples R China

[31] Xuzhou Tumor Hosp, Dept Endocrinol & Metab, Xuzhou 221005, Peoples R China

[32] Tianjin Med Univ, Dept Endocrinol & Metab, Metab Dis Hosp, Tianjin 300070, Peoples R China

[33] Wuhu 2 Peoples Hosp, Dept Endocrinol & Metab, Wuhu 241000, Peoples R China

[34] GA Regents Univ, Med Coll Georgia, Ctr Biotechnol & Genom Med, Augusta, GA 30912 USA

来源：

SCIENCE CHINA-LIFE SCIENCES | 2016年 / 59卷 / 09期

基金：

中国国家自然科学基金;

关键词：

autoantibodies; heterogeneity; islet failure; type; 1; diabetes; C-PEPTIDE; INSULIN; CHILDREN; MELLITUS; DISEASE; RISK; LADA; IDENTIFICATION; PATHOGENESIS; ASSOCIATION;

D O I：

10.1007/s11427-016-5052-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobinA1c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1DM patients (duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus.

引用

页码：930 / 939

页数：10

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