Trends in biological dosimetry: an overview

被引：11
作者：
Amaral, A
机构：
[1] Univ Fed Pernambuco, Dept Nucl Energy, BR-50740540 Recife, PE, Brazil
[2] Univ Paris 07, Lab Chim & Biophys Traceurs, Fac Med Xavier Bichat, F-75870 Paris 18, France
来源：
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY | 2002年 / 45卷
关键词：
biodosimetry; physical dosimetry; biomarkers; chromosome aberrations;
D O I：
10.1590/S1516-89132002000500017
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Biological dosimetry (biodosimetry) is based on investigations of induced biological effects (biomarkers) in order to Correlate them with radiation dose. Among the indicators employed in biodosimetry, scoring of chromosome aberrations is the most reliable method to quantify individual exposure to ionizing radiation. The technique, applied to circulating lymphocytes, has been developed into a routine procedure to evaluate the dose in the case of real or suspected accidental exposure. Considering the radiosensitivity of lymphocytes in vitro and in vivo as being the same, the dose affect relationship obtained after in vitro irradiation of blood has been widely used, with medicolegal value, for evaluating individual radiation exposure. This report presents an overview of strengths, limitations and perspectives on biodosimetry.
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页码：119 / 124
页数：6
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