Synthesis and cytotoxic evaluation of cis-locked and constrained analogues of combretastatin and combretastatin A4

被引：11
作者：
Lorion, Magali [1 ,2 ]
Agouridas, Vangelis [1 ,2 ]
Couture, Axel [1 ,3 ]
Deniau, Eric [1 ,2 ]
Grandclaudon, Pierre [1 ,2 ]
机构：
[1] Univ Lille Nord France, F-59000 Lille, France
[2] USTL, Lab Chim Organ Phys, EA CMF 4478, F-59655 Villeneuve Dascq, France
[3] CNRS, UMR 8181 UCCS, F-59655 Villeneuve Dascq, France
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 39期
关键词：
Combretastatins; Isoindolinones; Oxygen heterocycle; Oxidation; Anticancer agents; CONFORMATIONALLY RESTRICTED ANALOGS; ANTINEOPLASTIC AGENTS; BIOLOGICAL EVALUATION; A-4; ANALOGS; POTENT; ANTITUBULIN; TUBULIN; DESIGN; DERIVATIVES; RING;
D O I：
10.1016/j.tetlet.2010.07.120
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of cis-locked stilbenic compounds related to combretastatin and combretastatin A4 has been designed and synthesized. The cytotoxic effects of these rigid analogues were evaluated as well as their abilities to inhibit tubulin polymerization. (c) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5146 / 5149
页数：4
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