Effects of moderate-continuous and high-intensity interval aerobic training on cardiac function of spontaneously hypertensive rats

被引:2
作者
Suarez, Pedro Z. [1 ]
Natali, Antonio J. [1 ]
Mill, Jose G. [2 ]
de Rezende, Leonardo M. T. [1 ]
Soares, Leoncio L. [1 ]
Drummond, Filipe R. [3 ]
Cardoso, Lucas C. C. [1 ]
Reis, Emily C. C. [4 ]
Lavorato, Victor N. [5 ]
Carneiro-Junior, Miguel A. [1 ]
机构
[1] Univ Fed Vicosa UFV, Dept Phys Educ, Lab Exercise Biol, BR-36570000 Vicosa, MG, Brazil
[2] Univ Fed Espirito Santo UFES, Dept Physiol Sci, BR-29075210 Vitoria, ES, Brazil
[3] Univ Fed Vicosa UFV, Dept Gen Biol, BR-36570000 Vicosa, MG, Brazil
[4] Univ Fed Vicosa UFV, Dept Vet Med, BR-36570000 Vicosa, MG, Brazil
[5] Ctr Univ Governador Ozanam Coelho UNIFAGOC, Dept Phys Educ, BR-36506022 Uba, Brazil
关键词
Cardiomyocytes; cardiac function; calcium transient; hypertension; spontaneously hypertensive rats; aerobic training; LEFT-VENTRICULAR MYOCYTES; MECHANICAL-PROPERTIES; ELECTRICAL-PROPERTIES; NITRIC-OXIDE; EXERCISE; HEART; HYPERTROPHY; ECHOCARDIOGRAPHY; DISEASE; MODELS;
D O I
10.1177/15353702221110823
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The aim of this study was to verify the effects of moderate-intensity continuous (MICT) and high-intensity interval (HIIT) aerobic training on cardiac morphology and function and the mechanical properties of single cardiomyocytes in spontaneously hypertensive rats (SHR) in the compensated phase of hypertension. Sixteen-week-old male SHR and normotensive Wistar (WIS) rats were allocated to six groups of six animals each: SHR CONT or WIS CONT (control); SHR MICT or WIS MICT (underwent MICT, 30 min/day, five days per week for eight weeks); and SHR HIIT or WIS HIIT (underwent HIIT, 30 min/day, five days per week for eight weeks). Total exercise time until fatigue and maximum running speed were determined using a maximal running test before and after the experimental period. Systolic (SAP), diastolic (DAP), and mean (MAP) blood pressures were measured using tail plethysmography before and after the experimental period. Echocardiographic evaluations were performed at the end of the experimental period. The rats were euthanized after in vivo assessments, and left ventricular myocytes were isolated to evaluate global intracellular Ca2+ transient ([Ca2+](i)) and contractile function. Cellular measurements were performed at basal temperature (similar to 37 degrees C) at 3, 5, and 7 Hz. The results showed that both training programs increased total exercise time until fatigue and, consequently, maximum running speed. In hypertensive rats, MICT decreased SAP, DAP, MAP, interventricular septal thickness during systole and diastole, and the contraction amplitude at 5 Hz. HIIT increased heart weight and left ventricular wall thickness during systole and diastole and reduced SAP, MAP, and the time to peak [Ca2+](i) at all pacing frequencies. In conclusion, both aerobic training protocols promoted beneficial adaptations to cardiac morphology, function, and mechanical properties of single cardiomyocytes in SHR.
引用
收藏
页码:1691 / 1700
页数:10
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