SARS-CoV-2 virulence evolution: Avirulence theory, immunity and trade-offs

被引：25
作者：
Alizon, Samuel [1 ]
Sofonea, Mircea T. [1 ]
机构：
[1] Univ Montpellier, CNRS, MIVEGEC, IRD, Montpellier, France
来源：
JOURNAL OF EVOLUTIONARY BIOLOGY | 2021年 / 34卷 / 12期
关键词：
epidemiology; genomics; immune escape; immunopathology; maladaptation; trade-off; virus; INFECTION; DISEASE; HOST; TRANSMISSION; COEVOLUTION; DYNAMICS; HISTORY; MODEL;
D O I：
10.1111/jeb.13896
中图分类号：
Q14 [生态学（生物生态学）];
学科分类号：
071012 ; 0713 ;
摘要：
The COVID-19 pandemic has led to a resurgence of the debate on whether host-parasite interactions should evolve towards avirulence. In this review, we first show that SARS-CoV-2 virulence is evolving, before explaining why some expect the mortality caused by the epidemic to converge towards that of human seasonal alphacoronaviruses. Leaning on existing theory, we then include viral evolution into the picture and discuss hypotheses explaining why the virulence has increased since the beginning of the pandemic. Finally, we mention some potential scenarios for the future.
引用
收藏
页码：1867 / 1877
页数：11
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