Up for Mischief? IL-17/Th17 in the tumour microenvironment

The role of interleukin (IL)-17 and the IL-17-producing T helper (Th)17 cells in cancer has recently become the focus of extensive investigation. An expanding body of literature implicates Th17 cells and their hallmark cytokine in both pro-and anti-tumourigenic processes. In this review we describe their biological activities and outline the reciprocal interactions between Th17 cells and other cells of the immune system. We also discuss the evidence regarding their dual role in the tumour microenvironment. An understanding of the processes that regulate the pro-or anti-tumour activities of Th17 cell and IL-17 will allow the development of more effective means for cancer immunotherapy. Oncogene (2010) 29, 5653-5662; doi:10.1038/onc.2010.367; published online 23 August 2010