Evaluation of vitamin B12 and methylmalonic acid levels as markers with neuropathy in patients of type 2 diabetes mellitus

Many case reports have previously emerged revealing that vitamin B12 deficiency can create an insidious neuropathy that, if left untreated, can lead to the poor glycemic control in patients with type 2 diabetic mellitus (T2DM). To evaluate vitamin B12 and methylmalonic acid levels as markers with neuropathy in patients with type 2 diabetes mellitus. This study included (100) volunteers aged (40-80) years, who were divided into three groups: (40) nondiabetic volunteers as a control group, (30) patients with type 2 diabetes without vitamin B12 treatment, (30) patients with type 2 diabetes within vitamin B12 treatment. A questionnaire was filled out by volunteers, which included age, body mass (BMI) and symptoms of neuropathy. Serum was taken for chemical tests and blood samples for HbAic analysis. Data analysis was performed statistically by descriptive statistics, one-way ANOVA, and Chi-square. Significant difference was selected at the statistical level (P 0.05). There was a large statistically significant difference between the three groups of age, fasting blood sugar (FBS), HbAic, vitamin B12, and there was a no statistically significant difference between the three groups of body mass indexes (BMI) and methylmalonic acid (MMA) for patients of type 2 diabetes mellitus (T2DM). Further a difference was observed in the percentages of symptoms. The association was found between age and forget to speak symptom (p= 0.001), at the level of significance (P <= 0.05). By studying the symptoms of neuropathy, it turned out that when type 2 diabetes mellitus (T2DM) develops, many complications appear, including neuropathy. Likewise, when performing a vitamin B12 level test, it is best to have a confirmatory test such as a methylmalonic acid (MMA) test to confirm changes in vitamin B12 levels. The study found that there is a relationship between age and symptoms of forgetting to speak as neuropathy symptoms.