Uricase-containing coacervate microdroplets as enzyme active membrane-free protocells for detoxification of uric acid in serum

被引：20

作者：

Zhuang, Miaomiao ^{[1
,2
]}

Zhang, Yanwen ^{[2
]}

Zhou, Shaohong ^{[2
]}

Zhang, Yun ^{[1
]}

Wang, Kemin ^{[2
]}

Nie, Jinfang ^{[1
]}

Liu, Jianbo ^{[2
]}

机构：

[1] Guilin Univ Technol, Coll Chem & Bioengn, Guilin 541004, Peoples R China

[2] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn, Key Lab Bionanotechnol & Mol Engn Hunan Prov, Changsha 410082, Hunan, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 92期

基金：

中国国家自然科学基金;

关键词：

COMPLEX; DROPLETS; STABILIZATION; VESICLES; STEP;

D O I：

10.1039/c9cc07037k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Based on the unique property of preferential sequestration of guest molecules, coacervate microdroplets are proposed as enzyme active membrane-free protocells, in which uricase is loaded for efficient detoxification of uric acid in serum.

引用

页码：13880 / 13883

页数：4