Microwave Method for the Synthesis of Amantadine Hydrochloride

被引：0
|
作者：
Thinh Van Nguyen [1 ]
Hien Van Pham [1 ]
Duong Binh Vu [1 ]
Anh Tuan Dang [2 ]
Vu Khac Tran [2 ]
Chau Dinh Phan [2 ]
机构：
[1] Hanoi Univ Sci & Technol, Vietnam Mil Med Univ, Hanoi, Vietnam
[2] Hanoi Univ Sci & Technol, Sch Chem Engn, Hanoi, Vietnam
来源：
CHIANG MAI JOURNAL OF SCIENCE | 2018年 / 45卷 / 06期
关键词：
amantadine hydrochloride; adamantane; acetonitrile; N-(1-adamantyl)acetamide; microwave radiation; Parkinson's disease; GRIGNARD-REAGENTS; PRIMARY AMINES; ELECTROPHILIC AMINATION; O-SULFONYLOXIME;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
An easy and rapid method to prepare amantadine hydrochloride (1), which was used for the treatment of certain influenza infections type A and Parkinson's disease was developed. In this work, we report a microwave method, which was effective in heating and saving solvents, for the synthesis of amantadine hydrochloride from adamantane by Ritter-type reaction via N-(1-adamantyl)acetamide in a two-step procedure with an improved overall yield 71%. The reaction conditions were investigated to increase the overall yield and to shorten the reaction time, reduce the use of toxic reagents, solvents, rendering it more effective and environment-friendly
引用
收藏
页码：2454 / 2458
页数：5
相关论文
共 50 条
  • [41] Nanocrystalline hydroxyapatite bioceramic using microwave radiation: Synthesis and characterization
    Kalita, Samar J.
    Verma, Saurabh
    MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2010, 30 (02): : 295 - 303
  • [42] The Synthesis and Characterization of Ti-MCM-41 by Microwave Radiation
    Zhang, Juan
    Zhao, Dishun
    Liu, Mengshuai
    Li, Junpan
    ADVANCED MATERIALS AND PROCESSES II, PTS 1-3, 2012, 557-559 : 1411 - 1414
  • [43] Design, microwave synthesis, characterization and antimicrobial activity of imidazolone derivatives
    Banoon, Zainab Rabeea
    Mahmood, Rasha Shaker
    Hamad, Amenah Radhi
    Hussein, Zahraa Abed
    JOURNAL OF MOLECULAR STRUCTURE, 2025, 1322
  • [44] Microwave radiation-assisted synthesis of Pt-CNTs
    Zhong Qi-Ling
    Zhang Bing
    Ding Yue-Min
    Rao Gui-Shi
    Wang Guo-Fu
    Jiang Yu-Xiong
    Ren Bin
    Tian Zhong-Qun
    ACTA PHYSICO-CHIMICA SINICA, 2007, 23 (03) : 429 - 432
  • [45] Rapid synthesis of CaS:Ce3+,Sb3+ phosphor with submicron-scale by microwave radiation method and its luminescence
    Zhang, MS
    Zang, L
    RARE METAL MATERIALS AND ENGINEERING, 2002, 31 (01) : 69 - 72
  • [46] Microwave radiation method for rapid synthesis of Nb2O5@MoS2 as high-performance supercapacitor electrode materials
    Ran, Jing
    Yang, Tiantian
    Liu, Yafei
    Feng, Huixia
    Zhang, Xinghui
    Shi, Haixiong
    JOURNAL OF ENERGY STORAGE, 2023, 70
  • [47] New method for the synthesis of indenes
    Nenajdenko, VG
    Denisenko, DI
    Balenkova, ES
    RUSSIAN CHEMICAL BULLETIN, 2002, 51 (11) : 2090 - 2096
  • [48] New method for the synthesis of indenes
    V. G. Nenajdenko
    D. I. Denisenko
    E. S. Balenkova
    Russian Chemical Bulletin, 2002, 51 : 2090 - 2096
  • [49] Validation of a capillary zone electrophoresis method for determination of rimantadine hydrochloride in rimantadin100 tablets and the method application to dissolution test monitoring
    Pazourek, J
    Revilla, AL
    Gajdogová, D
    Havel, J
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2004, 30 (02) : 125 - 134
  • [50] Synthesis of Carbon Nanotubes Using Microwave Radiation: Technology, Properties, and Structure
    Shchegolkov, A., V
    Shchegolkov, Al, V
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2022, 92 (06) : 1168 - 1172
12345