Microwave Method for the Synthesis of Amantadine Hydrochloride

被引：0
|
作者：
Thinh Van Nguyen [1 ]
Hien Van Pham [1 ]
Duong Binh Vu [1 ]
Anh Tuan Dang [2 ]
Vu Khac Tran [2 ]
Chau Dinh Phan [2 ]
机构：
[1] Hanoi Univ Sci & Technol, Vietnam Mil Med Univ, Hanoi, Vietnam
[2] Hanoi Univ Sci & Technol, Sch Chem Engn, Hanoi, Vietnam
来源：
CHIANG MAI JOURNAL OF SCIENCE | 2018年 / 45卷 / 06期
关键词：
amantadine hydrochloride; adamantane; acetonitrile; N-(1-adamantyl)acetamide; microwave radiation; Parkinson's disease; GRIGNARD-REAGENTS; PRIMARY AMINES; ELECTROPHILIC AMINATION; O-SULFONYLOXIME;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
An easy and rapid method to prepare amantadine hydrochloride (1), which was used for the treatment of certain influenza infections type A and Parkinson's disease was developed. In this work, we report a microwave method, which was effective in heating and saving solvents, for the synthesis of amantadine hydrochloride from adamantane by Ritter-type reaction via N-(1-adamantyl)acetamide in a two-step procedure with an improved overall yield 71%. The reaction conditions were investigated to increase the overall yield and to shorten the reaction time, reduce the use of toxic reagents, solvents, rendering it more effective and environment-friendly
引用
收藏
页码：2454 / 2458
页数：5
相关论文
共 50 条
  • [1] An Improved Synthesis of Amantadine Hydrochloride
    Duong Binh Vu
    Thinh Van Nguyen
    Son Trung Le
    Chau Dinh Phan
    ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2017, 21 (11) : 1758 - 1760
  • [2] An Improved Procedure for the Synthesis of Amantadine Hydrochloride
    Binh Duong Vu
    Thi Phuong Dung Phan
    Thi Van Tran
    Phuong Linh Nguyen
    Dinh Chau Phan
    ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 2022, 54 (03) : 236 - 241
  • [3] A SIMPLE AND ECONOMICAL PROCEDURE FOR SYNTHESIS OF AMANTADINE HYDROCHLORIDE
    Dinh Chau Phan
    Tuan Anh Dang
    Huu Tung Nguyen
    Binh Duong Vu
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2019, 10 (09): : 4359 - 4366
  • [4] Efficient one-pot process for synthesis of antiviral drug amantadine hydrochloride
    Sudrik, Vilas
    Karpe, Dnyaneshwar
    Suryawanshi, Manohar
    Ukale, Dattatraya
    Bodkhe, Arjun
    Lawande, Shamrao
    JOURNAL OF CHEMICAL SCIENCES, 2024, 136 (02)
  • [5] Simple and Economical Process for Producing Amantadine Hydrochloride
    Phuong Dung Phan Thi
    Tuan Anh Dang
    Binh Duong Vu
    Dinh Chau Phan
    ACS OMEGA, 2022, 7 (06): : 4787 - 4790
  • [6] The Halogen Bond between Amantadine and Iodine and Its Application in the Determination of Amantadine Hydrochloride in Pharmaceuticals
    Xiao Qing Yan
    Hui Wang
    Wei Di Chen
    Wei Jun Jin
    Analytical Sciences, 2014, 30 : 365 - 370
  • [7] The Halogen Bond between Amantadine and Iodine and Its Application in the Determination of Amantadine Hydrochloride in Pharmaceuticals
    Yan, Xiao Qing
    Wang, Hui
    Di Chen, Wei
    Jin, Wei Jun
    ANALYTICAL SCIENCES, 2014, 30 (03) : 365 - 370
  • [8] Efficacy of amantadine hydrochloride in patients with chronic hepatitis C
    Hideji Nakamura
    Journal of Gastroenterology, 2001, 36 : 792 - 793
  • [9] Amantadine hydrochloride treatment in heredodegenerative ataxias: A double blind study
    Botez, MI
    BotezMarquard, T
    Elie, R
    Pedraza, OL
    Goyette, K
    Lalonde, R
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1996, 61 (03) : 259 - 264
  • [10] A Simple Process for the Synthesis of 1-Aminoadamantane Hydrochloride
    Van Hien Pham
    Thi Hang Tran
    Binh Duong Vu
    Huy Binh Le
    Huu Tung Nguyen
    Dinh Chau Phan
    ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 2020, 52 (01) : 77 - 80
12345