Is sudden infant death syndrome associated with Helicobacter pylori infection in children?

被引:12
作者
Elitsur, Y
Btriest, W
Sabet, Z
Neace, C
Jiang, CC
Thomas, E
机构
[1] Marshall Univ, Sch Med, Dept Pediat, Div Gastroenterol, Huntington, WV 25701 USA
[2] Marshall Univ, Sch Med, Dept Pathol, Huntington, WV 25701 USA
[3] E Tennessee State Univ, James H Quillen Coll Med, Dept Gastroenterol, Dept Internal Med, Johnson City, TN 37614 USA
[4] VA Med Ctr, Johnson City, TN USA
[5] State Dept Hlth & Human Serv, Charleston, WV USA
关键词
D O I
10.1046/j.1523-5378.2000.00035.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Helicobacter pylori infection has recently been implicated in the pathogenesis of sudden infant death syndrome (SIDS). We investigated this association. Twenty-five pairs of gastric and tracheal tissue specimens obtained from autopsies of 25 children with previous diagnoses of SIDS were available for this study. The presence of H. pylori organisms was evaluated by three different methods: histology (hematoxylin-eosin or Giemsa staining), immunohistochemistry, and nested polymerase chain reaction technique. We were unable to confirm the presence of H. pylori organisms by the first two methods. H. pylori DNA was identified by nested polymerase chain reaction in six different tissue specimens (stomach, 4; trachea, 2). In no case was H. pylori DNA detected in both tissues. We concluded that H. pylori infection is most likely not associated with SIDS.
引用
收藏
页码:227 / 231
页数:5
相关论文
共 34 条
  • [1] Changes in the epidemiologic profile of sudden infant death syndrome as rates decline among California infants: 1990-1995
    Adams, EJ
    Chavez, GF
    Steen, D
    Shah, R
    Iyasu, S
    Krous, HF
    [J]. PEDIATRICS, 1998, 102 (06) : 1445 - 1451
  • [2] Sudden infant death syndrome (SIDS): the search for the cause
    Addison, GM
    [J]. JOURNAL OF CLINICAL PATHOLOGY, 1998, 51 (06) : 419 - 419
  • [3] ANDERSON RN, 1997, MONTHLY VITAL STAT R, V45
  • [4] Seroepidemiological study of Helicobacter pylori infection in infancy
    Ashorn, M
    Miettinen, A
    Ruuska, T
    Laippala, P
    Maki, M
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 1996, 74 (02): : F141 - F142
  • [5] CARTUN RW, 1991, MODERN PATHOL, V4, P498
  • [6] CARTUN RW, 1990, MODERN PATHOL, V3, P16
  • [7] Helicobacter pylori infection is markedly increased in patients with autoimmune atrophic thyroiditis
    de Luis, DA
    Varela, C
    de La Calle, H
    Cantón, R
    de Argila, CM
    San Roman, AL
    Boixeda, D
    [J]. JOURNAL OF CLINICAL GASTROENTEROLOGY, 1998, 26 (04) : 259 - 263
  • [8] Prevalence of Helicobacter pylori infection in children from urban and rural West Virginia
    Elitsur, Y
    Short, JP
    Neace, C
    [J]. DIGESTIVE DISEASES AND SCIENCES, 1998, 43 (04) : 773 - 778
  • [9] FIEDOREK SC, 1991, PEDIATRICS, V88, P578
  • [10] Gasbarrini A, 1998, ITAL J GASTROENTEROL, V30, P115