Nickel-Catalyzed Electrochemical Reductive Relay Cross-Coupling of Alkyl Halides to Aryl Halides

被引：171

作者：

Jiao, Ke-Jin ^{[1
]}

Liu, Dong ^{[1
]}

Ma, Hong-Xing ^{[1
,2
]}

Qiu, Hui ^{[1
]}

Fang, Ping ^{[1
]}

Mei, Tian-Sheng ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Organometall Chem, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

[2] Yancheng Inst Technol, Sch Chem & Chem Engn, Yancheng 224051, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2020年 / 59卷 / 16期

基金：

中国博士后科学基金;

关键词：

arenes; cross-coupling; electrochemistry; nickel; reaction mechanisms; HETEROARYL HALIDES; C-C; BROMIDES; REMOTE; FUNCTIONALIZATION; COMPLEXES; ARYLATION; HYDROARYLATION; ACTIVATION; ESTERS;

D O I：

10.1002/anie.201912753

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly regioselective Ni-catalyzed electrochemical reductive relay cross-coupling between an aryl halide and an alkyl halide has been developed in an undivided cell. Various functional groups are tolerated under these mild reaction conditions, which provides an alternative approach for the synthesis of 1,1-diarylalkanes.

引用

页码：6520 / 6524

页数：5

共 88 条

[1]

Ackerman LKG, 2015, CHEM SCI, V6, P1115, DOI [10.1039/C4SC03106G, 10.1039/c4sc03106g]

[2] RATES AND MECHANISM OF BIPHENYL SYNTHESIS CATALYZED BY ELECTROGENERATED COORDINATIVELY UNSATURATED NICKEL-COMPLEXES [J].