Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

被引：37
|
作者：
Witzler, Markus [1 ]
Buechner, Dominik [1 ]
Shoushrah, Sarah Hani [1 ]
Babczyk, Patrick [1 ]
Baranova, Juliana [2 ]
Witzleben, Steffen [1 ]
Tobiasch, Edda [1 ]
Schulze, Margit [1 ]
机构：
[1] Bonn Rhein Sieg Univ Appl Sci, Dept Nat Sci, Von Liebig Str 20, D-53359 Rheinbach, Germany
[2] Univ Sao Paulo, Inst Chem, Dept Biochem, Lab Neurosci, Ave Prof Lineu Prestes 748,Vila Univ, BR-05508000 Sao Paulo, SP, Brazil
来源：
BIOMOLECULES | 2019年 / 9卷 / 12期
关键词：
polysaccharide; composites; bone tissue engineering; stem cells; osteogenesis; angiogenesis; COMPOSITE SCAFFOLDS; DRUG-RELEASE; CARBOXYMETHYL CELLULOSE; ENHANCED OSTEOGENESIS; INJECTABLE HYDROGELS; RECEPTOR ACTIVATOR; FRACTURE REPAIR; IN-VITRO; TISSUE; ALGINATE;
D O I：
10.3390/biom9120840
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bone tissue engineering is an ever-changing, rapidly evolving, and highly interdisciplinary field of study, where scientists try to mimic natural bone structure as closely as possible in order to facilitate bone healing. New insights from cell biology, specifically from mesenchymal stem cell differentiation and signaling, lead to new approaches in bone regeneration. Novel scaffold and drug release materials based on polysaccharides gain increasing attention due to their wide availability and good biocompatibility to be used as hydrogels and/or hybrid components for drug release and tissue engineering. This article reviews the current state of the art, recent developments, and future perspectives in polysaccharide-based systems used for bone regeneration.
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收藏
页数：26
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