Field evaluation of the clinical effectiveness of vaccines against pertussis, measles, rubella and mumps

被引：22
作者：
D'Argenio, P [1 ]
Citarella, A [1 ]
Selvaggi, MTM [1 ]
机构：
[1] Dept Publ Hlth, Epidemiol Unit, I-82100 Campobasso, Italy
来源：
VACCINE | 1998年 / 16卷 / 08期
关键词：
vaccines; surveillance; effectiveness;
D O I：
10.1016/S0264-410X(97)00270-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Beginning in March 1995, in the adjacent provinces of Benevento and Campobasso in Southern Italy, we carried out a sentinal, paediatrician-based surveillance on pertussis, measles, rubella and mumps with the aim of evaluating the health impact of new vaccination programmes and the objectives of describing the time-space trends and estimating the effectiveness of new vaccinations. The study population consisted of 16 500 children attended by 25 paediatricians. The estimated effectiveness of vaccines for pertussis, measles, and rubella were close to the expected values, although a very low effectiveness was calculated for the mumps vaccine. The comparison among children vaccinated with various strains showed a diseases odds ratio of 2.5 for the children vaccinated with Rubini strain. The effectiveness of this strain has to be verified in more rigorous settings. (C) 1998 Elsevier Science Ltd. All rights reserved.
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收藏
页码：818 / 822
页数：5
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