Preparation of novel azidopyrazole derivatives with anticipated cytotoxic and antimicrobial activities

被引：7

作者：

Ewies, Ewies F. ^{[1
]}

El-Hussieny, Marwa ^{[1
]}

El-Sayed, Naglaa F. ^{[1
]}

El-Shazly, Mohamed ^{[2
,3
]}

Chen, Yu-Cheng ^{[4
,5
]}

Liu, Yi-Chang ^{[6
,7
]}

机构：

[1] Natl Res Ctr, Organometall & Organometalloid Chem Dept, 33 El Bohouth St,PO 12622, Giza, Egypt

[2] Ain Shams Univ, Fac Pharm, Dept Pharmacognosy & Nat Prod Chem, Cairo, Egypt

[3] German Univ Cairo, Fac Pharm & Biotechnol, Dept Pharmaceut Biol, Cairo, Egypt

[4] China Med Univ, Program Canc Biol & Drug Discovery, Taichung, Taiwan

[5] Acad Sinica, Taichung, Taiwan

[6] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Hematol Oncol, Kaohsiung, Taiwan

[7] Kaohsiung Med Univ, Coll Med, Fac Med, Dept Internal Med, Kaohsiung, Taiwan

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 03期

关键词：

CELL BIOLOGY; ANTICANCER;

D O I：

10.1002/jhet.3747

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reactions of azidopyrazole with some of primary amines and active methylene compounds were studied. Structures of the prepared compounds were identified using spectroscopic techniques. The reactions mechanisms were also proposed. The cytotoxic and antimicrobial activities were also examined for the newly synthesized compounds.

引用

页码：965 / 977

页数：13

共 33 条

[1] Chemistry of Phosphonium Ylides. Part 39: Facile Synthesis of Aziridine, Pyridine, Pyrolotriazole Chromenones and Azaphosphinin Chromenones as Antitumor Agents [J].