Distearoylphosphatidylethanolamine-based liposomes for ultrasound-mediated drug delivery

被引：66

作者：

Evjen, Tove J. ^{[1
,2
]}

Nilssen, Esben A. ^{[1
]}

Rognvaldsson, Sibylla ^{[1
]}

Brandl, Martin ^{[2
]}

Fossheim, Sigrid L. ^{[1
]}

机构：

[1] Epitarget AS, N-0307 Oslo, Norway

[2] Univ Tromso, Dept Pharm, Tromso, Norway

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2010年 / 75卷 / 03期

关键词：

Liposome; Lipids; Ultrasound; Drug delivery; Cancer; Doxorubicin; STERICALLY STABILIZED LIPOSOMES; PH-SENSITIVE LIPOSOMES; HII PHASE-TRANSITIONS; TRIGGERED RELEASE; SOLID TUMORS; UNILAMELLAR LIPOSOMES; CHOLESTEROL; PHOSPHATIDYLETHANOLAMINES; PERMEABILIZATION; BILAYERS;

D O I：

10.1016/j.ejpb.2010.04.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The ability of ultrasound (US) to permeabilize phospholipid membranes has opened the potential of using US as a means to enhance delivery of anti-cancer drugs to tumour cells via liposomes. In this study, novel US sensitive or sonosensitive doxorubicin-containing liposomes based on 1,2 distearoyl-sn-glycero-3-phosphatidylethanolamine (DSPE) as the main lipid component are reported. A variety of lipid bilayer compositions was studied with respect to in vitro US triggered release of drug as well as serum stability in terms of drug retention, using experimental design. The multivariate data analysis indicated a strong correlation between DSPE content and sonosensitivity, both alone and in interplay with cholesterol. The most optimal formulation showed approximately 70% release of doxorubicin after 6 min of US exposure. This represented a 7-fold increase in release extent when compared to standard pegylated liposomal doxorubicin. The significant enhancement in sonosensitivity of the liposomes shows the potential of engineering liposomal lipid composition for US-mediated drug delivery. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：327 / 333

页数：7

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