Juvenile Myelomonocytic Leukemia in a Premature Neonate Mimicking Neonatal Sepsis

被引：4

作者：

Lee, Ming-Luen ^{[1
,2
]}

Yen, Hsiu-Ju ^{[1
,2
]}

Chen, Shu-Jen ^{[1
,2
]}

Hung, Giun-Yi ^{[1
,2
]}

Tsao, Pei-Chen ^{[1
,2
,3
]}

Soong, Wen-Jue ^{[1
,2
,3
]}

机构：

[1] Taipei Vet Gen Hosp, Dept Pediat, 201 Shih Pai Rd,Sect 2, Taipei 11217, Taiwan

[2] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[3] Natl Yang Ming Univ, Inst Emergency & Crit Care Med, Taipei 112, Taiwan

来源：

PEDIATRICS AND NEONATOLOGY | 2016年 / 57卷 / 02期

关键词：

juvenile myelomonocytic leukemia; newborn; premature neonate; NOONAN-SYNDROME; DISORDERS; CHILDHOOD; PTPN11;

D O I：

10.1016/j.pedneo.2013.06.009

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Juvenile myelomonocytic leukemia (JMML) is a rare hematologic malignancy in children. Its presentations include anemia, thrombocytopenia, monocytosis, skin rash, marked hepatomegaly, and/or splenomegaly. Fever and respiratory involvement are common. Here, we report a case of a premature neonate with initial symptoms of respiratory distress. She gradually developed clinical manifestations of JMML that mimicked neonatal sepsis. Three weeks after birth, JMML was diagnosed. This is the first reported case of JMML presenting in a premature infant in Taiwan. Copyright (C) 2013, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved.

引用

页码：149 / 152

页数：4

共 14 条

[1] Juvenile myelomonocytic leukemia
Arico, M
Biondi, A
Pui, CH
[J]. BLOOD, 1997, 90 (02) : 479 - 488
[2] Juvenile myelomonocytic leukemia: A report from the 2nd International JMML Symposium
Chan, Rebecca J.
Cooper, Todd
Kratz, Christian P.
Weiss, Brian
Loh, Mignon L.
[J]. LEUKEMIA RESEARCH, 2009, 33 (03) : 355 - 362
[3] Differentiating juvenile myelomonocytic leukemia from chronic myeloid leukemia in childhood
Chang, YH
Jou, ST
Lin, DT
Lu, MY
Lin, KH
[J]. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2004, 26 (04) : 236 - 242
[4] Clinical Features, Molecular Diagnosis, and Treatment Outcome of Infants with Leukemia in Taiwan
Chen, Shih-Hsiang
Yang, Chao-Ping
Hung, Iou-Jih
Jaing, Tang-Her
Shih, Lee-Yung
Tsai, Ming-Horng
[J]. PEDIATRIC BLOOD & CANCER, 2010, 55 (07) : 1264 - 1271
[5] Respiratory failure, juvenile myelomonocytic leukemia, and neonatal Noonan syndrome
Cheong, Jeanie L. Y.
Moorkamp, Martina. H.
[J]. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2007, 29 (04) : 262 - 264
[6] Transient Myeloproliferation Mimicking JMML Associated With Parvovirus Infection of Infancy
Gupta, Nidhi
Gupta, Ritu
Bakhshi, Sameer
[J]. PEDIATRIC BLOOD & CANCER, 2009, 52 (03) : 411 - 413
[7] Diagnosing myelodysplastic/myeloproliferative neoplasms: laboratory testing strategies to exclude other disorders
Hall, J.
Foucar, K.
[J]. INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2010, 32 (06) : 559 - 571
[8] Malignant Diseases in Noonan Syndrome and Related Disorders
Hasle, Henrik
[J]. HORMONE RESEARCH, 2009, 72 : 8 - 14
[9] Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukaemia
Loh, Mignon L.
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2011, 152 (06) : 677 - 687
[10] Niemeyer CM, 1997, BLOOD, V89, P3534

← 1 2 →