Organocatalytic formal [3+3] cyclization of α-(6-indolyl) propargylic alcohols

被引：5

作者：

Yue, Zhibin ^{[1
]}

Wang, Ziyang ^{[1
]}

Zhang, Yunfeng ^{[2
]}

Chen, Xuling ^{[3
,4
]}

Li, Pengfei ^{[3
,4
]}

Li, Wenjun ^{[1
]}

机构：

[1] Qingdao Univ, Sch Pharm, Dept Med Chem, Qingdao 266021, Peoples R China

[2] Qingdao Municipal Hosp, Dept Orthoped, Qingdao 266011, Peoples R China

[3] Southern Univ Sci & Technol SUSTech, Shenzhen Grubbs Inst, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China

[4] Southern Univ Sci & Technol SUSTech, Dept Chem, Shenzhen 518055, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 32期

关键词：

COUMARINS; ANNULATION; EFFICIENT; 4-HYDROXYCOUMARINS; PYRANOCOUMARINS; STRATEGIES; ACCESS; WATER;

D O I：

10.1039/d2ob01206e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

With the aid of acetic acid, a 1,10-conjugate addition-mediated formal [3 + 3] cyclization of alkynyl indole imine methides formed in situ from alpha-(6-indolyl) propargylic alcohols with 1,3-dicarbonyl compounds such as 4-hydroxycoumarins and cyclohexane-1,3-diones was developed, which provided robust access to a wide range of pyranocoumarin and pyran derivatives containing an indole skeleton with high efficiency under mild conditions.

引用

页码：6334 / 6338

页数：5

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