Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes

被引：75

作者：

Ludwig, Barbara ^{[1
,2
,3
,4
]}

Ludwig, Stefan ^{[5
]}

Steffen, Anja ^{[1
,2
,3
,4
]}

Knauf, Yvonne ^{[6
]}

Zimerman, Baruch ^{[7
]}

Heinke, Sophie ^{[8
]}

Lehmann, Susann ^{[1
]}

Schubert, Undine ^{[1
]}

Schmid, Janine ^{[1
]}

Bleyer, Martina ^{[6
]}

Schoenmann, Uwe ^{[6
]}

Colton, Clark K. ^{[9
]}

Bonifacio, Ezio ^{[10
]}

Solimena, Michele ^{[2
,3
,4
,11
]}

Reichel, Andreas ^{[1
]}

Schally, Andrew V. ^{[12
,13
,14
,15
,16
,17
,18
]}

Rotem, Avi ^{[7
]}

Barkai, Uriel ^{[7
]}

Grinberg-Rashi, Helena ^{[7
]}

Kaup, Franz-Josef ^{[6
]}

Avni, Yuval ^{[7
]}

Jones, Peter ^{[19
]}

Bornstein, Stefan R. ^{[1
,2
,3
,4
,19
]}

机构：

[1] Univ Hosp Carl Gustav Carus, Dept Med 3, D-01307 Dresden, Germany

[2] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Helmholtz Ctr Munich, Paul Langerhans Inst Dresden, D-01307 Dresden, Germany

[3] Tech Univ Dresden, Fac Med, D-01307 Dresden, Germany

[4] Gernam Ctr Diabet Res DZD eV, D-85764 Neuherberg, Germany

[5] Univ Hosp Carl Gustav Carus, Dept Surg, D-01307 Dresden, Germany

[6] Leibniz lnst Primate Res, German Primate Ctr, Pathol Unit, D-37077 Gottingen, Germany

[7] Beta O2 Technol, IL-49511 Petah Tiqwa, Israel

[8] Univ Hosp Carl Gustav Carus, Dept Pediat, D-01307 Dresden, Germany

[9] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[10] Tech Univ Dresden, DFG Ctr Regenerat Therapies Dresden, D-01307 Dresden, Germany

[11] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany

[12] Univ Miami, Miller Sch Med, Dept Pathol, Miami, FL 33136 USA

[13] Univ Miami, Miller Sch Med, Dept Med, Div Hematol Oncol, Miami, FL 33136 USA

[14] Univ Miami, Miller Sch Med, Dept Med, Div Endocrinol Diabet & Metab, Miami, FL 33136 USA

[15] Vet Affairs Med Ctr, Miami, FL 33136 USA

[16] South Florida Vet Affairs Fdn Res & Educ, Miami, FL 33136 USA

[17] Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA

[18] Univ Miami, Miller Sch Med, lnterdisciplinary Stem Cell Inst, Miami, FL 33136 USA

[19] Kings Coll London, Fac Life Sci & Med, Div Diabet & Nutr Sci, London SE1 1UL, England

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2017年 / 114卷 / 44期

关键词：

diabetes; porcine islets; beta-cell replacement; immune barrier; HORMONE-RELEASING-HORMONE; BIOARTIFICIAL PANCREAS; TRANSPLANTATION; FUTURE; MINIPIGS; AGONISTS;

D O I：

10.1073/pnas.1708420114

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macro-encapsulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions.

引用

页码：11745 / 11750

页数：6

共 29 条

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