Enhanced expression of caveolin-1 possesses diagnostic and prognostic value and promotes cell migration, invasion and sunitinib resistance in the clear cell renal cell carcinoma

被引：32

作者：

Ruan, HaiLong ^{[1
]}

Li, Xiang ^{[1
]}

Yang, HongMei ^{[2
]}

Song, ZhengShuai ^{[1
]}

Tong, JunWei ^{[1
]}

Cao, Qi ^{[1
]}

Wang, KeShan ^{[1
]}

Xiao, Wen ^{[1
]}

Xiao, HaiBin ^{[1
]}

Chen, XuanYu ^{[1
,3
,4
]}

Xu, GuangHua ^{[1
]}

Bao, Lin ^{[1
]}

Xiong, ZhiYong ^{[1
]}

Yuan, ChangFei ^{[1
]}

Liu, Lei ^{[1
]}

Qu, Yan ^{[2
]}

Hu, WenJun ^{[2
]}

Gao, YaoYing ^{[2
]}

Ru, ZeYuan ^{[2
]}

Chen, Ke ^{[1
]}

Zhang, XiaoPing ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Urol, 1277 Jiefang Ave, Wuhan 430022, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Sch Basic Med, Dept Pathogen Biol, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China

[3] Zhejiang Prov Peoples Hosp, Dept Urol, Hangzhou 310014, Zhejiang, Peoples R China

[4] Augusta Univ, Med Coll Georgia, Dept Neurosci & Regenerat Med, Augusta, GA 30912 USA

来源：

EXPERIMENTAL CELL RESEARCH | 2017年 / 358卷 / 02期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

CAV1; Sunitinib-resistance; Invasion; Prognosis; Diagnosis; ccRCC; DRUG-RESISTANCE; GENE-EXPRESSION; POOR-PROGNOSIS; FREE SURVIVAL; CANCER CELLS; OVEREXPRESSION; METASTASIS; CHEMORESISTANCE; INHIBITION; DENSITY;

D O I：

10.1016/j.yexcr.2017.07.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Caveolin-1 (CAV1) has been identified to be up-regulated in many cancers, including clear cell renal cell carcinoma (ccRCC). However, its potential function is still unclear in ccRCC. In this study, we demonstrated that CAV1 was frequently overexpressed in renal cell carcinoma tissues and cells, and was significantly associated with various clinicopathological parameters. In addition, high CAV1 expression was associated with poor disease-free survival (DFS) rate and could serve as a useful diagnostic indicator in ccRCC patients with different clinicopathological stages. Functional experiments demonstrated that CAV1 knockdown inhibited cell migration and invasion, whereas overexpression of CAV1 promoted cell migration and invasion in ccRCC. Moreover, CAV1 expression was up-regulated in sunitinib-resistant renal cancer cell lines, and its over-expression promoted sunitinib resistance. In general, our results confirm that CAV1 plays an important role in the metastasis of kidney cancer and induces sunitinib resistance, so CAV1 function suppression may become a promising clinical treatment strategy during renal cell carcinoma metastasis and sunitinib resistance.

引用

页码：269 / 278

页数：10

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