Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box

被引：233

作者：

Kronstad, James W. ^{[1
,2
]}

Attarian, Rodgoun ^{[1
,2
]}

Cadieux, Brigitte ^{[1
,2
]}

Choi, Jaehyuk ^{[1
,2
]}

D'Souza, Cletus A. ^{[1
,2
]}

Griffiths, Emma J. ^{[1
,2
]}

Geddes, Jennifer M. H. ^{[1
,2
]}

Hu, Guanggan ^{[1
,2
]}

Jung, Won Hee ^{[3
]}

Kretschmer, Matthias ^{[1
,2
]}

Saikia, Sanjay ^{[1
,2
]}

Wang, Joyce ^{[1
,2
]}

机构：

[1] Univ British Columbia, Dept Microbiol & Immunol, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada

[2] Univ British Columbia, Fac Land & Food Syst, Vancouver, BC V6T 1Z4, Canada

[3] Chung Ang Univ, Dept Biotechnol, Ansung 456756, Kyunggi, South Korea

来源：

NATURE REVIEWS MICROBIOLOGY | 2011年 / 9卷 / 03期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

CENTRAL-NERVOUS-SYSTEM; MURINE PULMONARY INFECTION; BLOOD-BRAIN-BARRIER; CAPSULAR POLYSACCHARIDE; EXTRACELLULAR VESICLES; NEOFORMANS INFECTION; SEXUAL REPRODUCTION; PACIFIC-NORTHWEST; VANCOUVER-ISLAND; GENE-EXPRESSION;

D O I：

10.1038/nrmicro2522

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cryptococcus neoformans is generally considered to be an opportunistic fungal pathogen because of its tendency to infect immunocompromised individuals, particularly those infected with HIV. However, this view has been challenged by the recent discovery of specialized interactions between the fungus and its mammalian hosts, and by the emergence of the related species Cryptococcus gattii as a primary pathogen of immunocompetent populations. In this Review, we highlight features of cryptococcal pathogens that reveal their adaptation to the mammalian environment. These features include not only remarkably sophisticated interactions with phagocytic cells to promote intracellular survival, dissemination to the central nervous system and escape, but also surprising morphological and genomic adaptations such as the formation of polyploid giant cells in the lung.

引用

页码：193 / 203

页数：11

共 106 条

[1] Cell-to-cell spread and massive vacuole formation after Cryptococcus neoformans infection of murine macrophages [J].