Retinal involvement in dementia with Lewy bodies: A clue to hallucinations?

被引：45

作者：

Maurage, CA

Ruchoux, MM

de Vos, R

Surguchov, A

Destree, A

机构：

[1] Ctr Hosp Reg & Univ Lille, R Salengro Hosp, Dept Neuropathol, MENRT,EA 2691, F-59037 Lille, France

[2] Dept Pathol E Netherlands, Enschede, Netherlands

[3] VAMC, Neurobiol Res Lab, Kansas City, KS USA

[4] Univ Kansas, Med Ctr, Kansas City, KS 66103 USA

[5] Ctr Hosp Reg & Univ Lille, R Salengro Hosp, Dept Neurol, F-59037 Lille, France

[6] Ctr Hosp Reg & Univ Lille, R Salengro Hosp, EA Menrit 2683, F-59037 Lille, France

来源：

ANNALS OF NEUROLOGY | 2003年 / 54卷 / 04期

关键词：

D O I：

10.1002/ana.10730

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Visual hallucinations are a core feature of dementia with Lewy bodies. Their pathophysiology is not well understood, because neither clinical nor histological data have shown their basic mechanisms. Here, we report the presence of pale inclusions in the outer plexiform layer of the retina in a patient with dementia with Lewy bodies. These inclusions are related to cytoskeletal disorganization of the cones at ultrastructural level and modifications of the immunohistochemical pattern of distribution of synucleins in the retina. These modifications may participate in the visual impairment in dementia with Lewy bodies.

引用

页码：542 / 547

页数：6

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