Sweet and Umami Taste: Natural Products, Their Chemosensory Targets, and Beyond

被引:140
作者
Behrens, Maik [2 ]
Meyerhof, Wolfgang [2 ]
Hellfritsch, Caroline [1 ]
Hofmann, Thomas [1 ]
机构
[1] Tech Univ Munich, Chair Food Chem & Mol Sensory Sci, D-85354 Freising Weihenstephan, Germany
[2] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Genet, D-14558 Nuthetal, Germany
关键词
molecular recognition; natural products; receptors; signal transduction; taste; AMINO-ACID-SEQUENCE; METABOTROPIC GLUTAMATE-RECEPTOR; PROTEIN THAUMATIN-I; MAMMALIAN TASTE; PLANT-ORIGIN; CRYSTAL-STRUCTURE; ALPHA-GUSTDUCIN; NONVOLATILE SENSOMETABOLOME; SENSORY CHARACTERIZATION; NONNUTRITIVE SWEETENERS;
D O I
10.1002/anie.201002094
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Figure Presented) A question of taste: Much of our appreciation of food is due to the excitement of the "sweet" and "umami" taste. This Review gives a survey of compounds that elicit the sweet or umami taste. It will highlight the activation of the taste receptors and signal transduction, which induces neural activity and is conveyed to the cerebral cortex to represent the taste quality (the picture shows a binding site of a sweet taste receptor. © 2011 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:2220 / 2242
页数:23
相关论文
共 210 条
[1]   A novel family of mammalian taste receptors [J].
Adler, E ;
Hoon, MA ;
Mueller, KL ;
Chandrashekar, J ;
Ryba, NJP ;
Zuker, CS .
CELL, 2000, 100 (06) :693-702
[2]  
[Anonymous], 2009, OFFICIAL J EUROPEAN
[3]   TASTES OF L-GLUTAMYL OLIGOPEPTIDES IN RELATION TO THEIR CHROMATOGRAPHIC PROPERTIES [J].
ARAI, S ;
YAMASHITA, M ;
NOGUCHI, M ;
FUJIMAKI, M .
AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1973, 37 (01) :151-156
[4]   Positional cloning of the mouse saccharin preference (Sac) locus [J].
Bachmanov, AA ;
Li, X ;
Reed, DR ;
Ohmen, JD ;
Li, SR ;
Chen, ZY ;
Tordoff, MG ;
de Jong, PJ ;
Wu, CY ;
West, DB ;
Chatterjee, A ;
Ross, DA ;
Beauchamp, GK .
CHEMICAL SENSES, 2001, 26 (07) :925-933
[5]   Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste buds [J].
Bartel, Dianna L. ;
Sullivan, Susan L. ;
Lavoie, Elise G. ;
Sevigny, Jean ;
Finger, Thomas E. .
JOURNAL OF COMPARATIVE NEUROLOGY, 2006, 497 (01) :1-12
[6]   Synthesis and sensory characterization of novel umami-tasting glutamate glycoconjugates [J].
Beksan, E ;
Schieberle, P ;
Robert, F ;
Blank, I ;
Fay, LB ;
Schlichtherle-Cerny, H ;
Hofmann, T .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (18) :5428-5436
[7]   STRUCTURE OF MONELLIN AND ITS RELATION TO SWEETNESS OF PROTEIN [J].
BOHAK, Z ;
LI, SL .
BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 427 (01) :153-170
[8]  
Borrego F, 2001, Food Sci Technol, P87
[9]   Overview: The history, technical function and safety of rebaudioside A, a naturally occurring steviol glycoside, for use in food and beverages [J].
Carakostas, M. C. ;
Curry, L. L. ;
Boilea, A. C. ;
Brusick, Dj. .
FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (07) :S1-S10
[10]   The receptors and cells for mammalian taste [J].
Chandrashekar, Jayaram ;
Hoon, Mark A. ;
Ryba, Nicholas J. P. ;
Zuker, Charles S. .
NATURE, 2006, 444 (7117) :288-294