Novel trends in celiac disease

被引：21
作者：
Matthias, Torsten [1 ]
Neidhoefer, Sandra [1 ]
Pfeiffer, Sascha [2 ]
Prager, Kai [2 ]
Reuter, Sandra [1 ]
Gershwin, M. Eric [3 ]
机构：
[1] AESKU KIPP Inst, D-55234 Wendelsheim, Germany
[2] AESKU Diagnost GmbH & Co KG, Wendelsheim, Germany
[3] Univ Calif Davis, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA
来源：
CELLULAR & MOLECULAR IMMUNOLOGY | 2011年 / 8卷 / 02期
关键词：
celiac disease; tissue transglutaminase; celiac neo-epitope; gluten; diagnostic marker; GLUTEN-FREE DIET; TISSUE TRANSGLUTAMINASE; GLIADIN PEPTIDES; DIAGNOSTIC-ACCURACY; STRUCTURAL BASIS; PREVALENCE; TESTS; ANTIBODIES; SEROLOGY; GENETICS;
D O I：
10.1038/cmi.2010.68
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Celiac disease (CD) is one of the most common food intolerances in developed world. It affects genetically susceptible individuals and has severe consequences if it remains undiagnosed. A disease known for more than a century, it is still the focus for experts from various fields of research and development. Geneticists, pathologists, immunologists, food engineers and dieticians share their knowledge and expertise to improve the conditions of CD patients. With new insights in the pathomechanism of gluten processing and antigen presentation in CD, it was possible to improve the diagnostic antigen mimicking the primary epitope in CD. These celiac neo-epitopes are comprised of a complex of gliadin peptides crosslinked with transglutaminase (tTg). They are an early diagnostic marker for CD which occurs up to 6 months earlier than classical markers known to miss a certain amount of CD patients. Cellular & Molecular Immunology (2011) 8, 121-125; doi:10.1038/cmi.2010.68; published online 31 January 2011
引用
收藏
页码：121 / 125
页数：5
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