Rhodium-Catalyzed Asymmetric 1,4-Addition of Sodium Tetraarylborates to β,β-Disubstituted α,β-Unsaturated Esters

被引：66
|
作者：
Shintani, Ryo [1 ]
Hayashi, Tamio [1 ]
机构：
[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 02期
关键词：
QUATERNARY STEREOGENIC CENTERS; 5-(1-ARYLALKYLIDENE) MELDRUMS ACIDS; CONJUGATE ADDITION; ENANTIOSELECTIVE SYNTHESIS; TRISUBSTITUTED ENONES; DIALKYLZINC REAGENTS; GRIGNARD-REAGENTS; ARYLZINC REAGENTS; ARYLBORONIC ACIDS; CARBON CENTERS;
D O I：
10.1021/ol102674z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A rhodium-catalyzed 1,4-addition of sodium tetraarylborates to beta,beta-disubstituted alpha,beta-unsaturated esters has been developed. Highly efficient asymmetric catalysis has also been described to create quaternary carbon stereocenters at the beta-position of esters by tuning the ester group of substrates and employing a readily available chiral diene ligand.
引用
收藏
页码：350 / 352
页数：3
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