Expression of IL-17 mRNA in ovarian cancer

被引：182
作者：
Kato, T [1 ]
Furumoto, H [1 ]
Ogura, T [1 ]
Onishi, Y [1 ]
Irahara, M [1 ]
Yamano, S [1 ]
Kamada, M [1 ]
Aono, T [1 ]
机构：
[1] Univ Tokushima, Sch Med, Dept Obstet & Gynecol, Tokushima 7708503, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 282卷 / 03期
关键词：
IL-17; ovarian cancer; angiogenesis;
D O I：
10.1006/bbrc.2001.4618
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
IL-17 is considered as a proinflammatory cytokine. We have demonstrated IL-17 is an angiogenic factor and promotes tumor growth in murine tumor models. In this report, we investigated the expression of IL-17 mRNA by RT-PCR and the relationship between IL-17 expression and microvascular density in ovarian cancer. IL-17 mRNA was expressed in 11 (64.7%) of 17 ovarian cancer. And the average number of blood vessels observed in IL-17 positive tumors (173.4 +/- 55.1/ mma) was significantly higher than that in negative tumors (107.7 +/- 57.8/mm(2)). These results indicated IL-17 is expressed in a considerable proportion of ovarian cancer and promotes tumor angiogenesis. There was no significant relationship between IL-17 expression and clinicopathologic parameters. (C) 2001 Academic Press.
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收藏
页码：735 / 738
页数：4
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