Expression of IL-17 mRNA in ovarian cancer

被引：182

作者：

Kato, T ^{[1
]}

Furumoto, H ^{[1
]}

Ogura, T ^{[1
]}

Onishi, Y ^{[1
]}

Irahara, M ^{[1
]}

Yamano, S ^{[1
]}

Kamada, M ^{[1
]}

Aono, T ^{[1
]}

机构：

[1] Univ Tokushima, Sch Med, Dept Obstet & Gynecol, Tokushima 7708503, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 282卷 / 03期

关键词：

IL-17; ovarian cancer; angiogenesis;

D O I：

10.1006/bbrc.2001.4618

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IL-17 is considered as a proinflammatory cytokine. We have demonstrated IL-17 is an angiogenic factor and promotes tumor growth in murine tumor models. In this report, we investigated the expression of IL-17 mRNA by RT-PCR and the relationship between IL-17 expression and microvascular density in ovarian cancer. IL-17 mRNA was expressed in 11 (64.7%) of 17 ovarian cancer. And the average number of blood vessels observed in IL-17 positive tumors (173.4 +/- 55.1/ mma) was significantly higher than that in negative tumors (107.7 +/- 57.8/mm(2)). These results indicated IL-17 is expressed in a considerable proportion of ovarian cancer and promotes tumor angiogenesis. There was no significant relationship between IL-17 expression and clinicopathologic parameters. (C) 2001 Academic Press.

引用

页码：735 / 738

页数：4

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