TIN-X: target importance and novelty explorer

被引：21

作者：

Cannon, Daniel C. ^{[1
]}

Yang, Jeremy J. ^{[1
]}

Mathias, Stephen L. ^{[1
]}

Ursu, Oleg ^{[1
]}

Mani, Subramani ^{[1
]}

Waller, Anna ^{[2
]}

Schurer, Stephan C. ^{[3
]}

Jensen, Lars Juhl ^{[4
]}

Sklar, Larry A. ^{[2
,5
]}

Bologa, Cristian G. ^{[1
]}

Oprea, Tudor I. ^{[1
]}

机构：

[1] Univ New Mexico, Sch Med, Translat Informat Div, Dept Internal Med, Albuquerque, NM 87131 USA

[2] Univ New Mexico, Comprehens Canc Ctr, UNM Ctr Mol Discovery, Albuquerque, NM 87131 USA

[3] Univ Miami, Miller Sch Med, Dept Mol & Cellular Pharmacol, Miami, FL 33136 USA

[4] Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Prot Res, DK-2200 Copenhagen N, Denmark

[5] Univ New Mexico, Dept Pathol, Albuquerque, NM 87131 USA

来源：

BIOINFORMATICS | 2017年 / 33卷 / 16期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1093/bioinformatics/btx200

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The increasing amount of peer-reviewed manuscripts requires the development of specific mining tools to facilitate the visual exploration of evidence linking diseases and proteins. Results: We developed TIN-X, the Target Importance and Novelty eXplorer, to visualize the association between proteins and diseases, based on text mining data processed from scientific literature. In the current implementation, TIN-X supports exploration of data for G-protein coupled receptors, kinases, ion channels, and nuclear receptors. TIN-X supports browsing and navigating across proteins and diseases based on ontology classes, and displays a scatter plot with two proposed new bibliometric statistics: Importance and Novelty.

引用

页码：2601 / 2603

页数：3

共 6 条

[1] Pharos: Collating protein information to shed light on the druggable genome [J].

Dac-Trung Nguyen ;

Mathias, Stephen ;

Bologa, Cristian ;

Brunak, Soren ;

Fernandez, Nicolas ;

Gaulton, Anna ;

Hersey, Anne ;

Holmes, Jayme ;

Jensen, Lars Juhl ;

Karlsson, Anneli ;

Liu, Guixia ;

Ma'ayan, Avi ;

Mandava, Geetha ;

Mani, Subramani ;

Mehta, Saurabh ;

Overington, John ;

Patel, Juhee ;

Rouillard, Andrew D. ;

Schurer, Stephan ;

Sheils, Timothy ;

Simeonov, Anton ;

Sklar, Larry A. ;

Southall, Noel ;

Ursu, Oleg ;

Vidovic, Dusica ;

Waller, Anna ;

Yang, Jeremy ;

Jadhav, Ajit ;

Oprea, Tudor I. ;

Guha, Rajarshi .

NUCLEIC ACIDS RESEARCH, 2017, 45 (D1) :D995-D1002

[2] Biomedical language processing: What's beyond PubMed? [J].

Hunter, L ;

Cohen, KB .

MOLECULAR CELL, 2006, 21 (05) :589-594

[3] Disease Ontology 2015 update: an expanded and updated database of human diseases for linking biomedical knowledge through disease data [J].

Kibbe, Warren A. ;

Arze, Cesar ;

Felix, Victor ;

Mitraka, Elvira ;

Bolton, Evan ;

Fu, Gang ;

Mungall, Christopher J. ;

Binder, Janos X. ;

Malone, James ;

Vasant, Drashtti ;

Parkinson, Helen ;

Schriml, Lynn M. .

NUCLEIC ACIDS RESEARCH, 2015, 43 (D1) :D1071-D1078

[4] The SPECIES and ORGANISMS Resources for Fast and Accurate Identification of Taxonomic Names in Text [J].

Pafilis, Evangelos ;

Frankild, Sune P. ;

Fanini, Lucia ;

Faulwetter, Sarah ;

Pavloudi, Christina ;

Vasileiadou, Aikaterini ;

Arvanitidis, Christos ;

Jensen, Lars Juhl .

PLOS ONE, 2013, 8 (06)

[5] DISEASES: Text mining and data integration of disease-gene associations [J].

Pletscher-Frankild, Sune ;

Palleja, Albert ;

Tsafou, Kalliopi ;

Binder, Janos X. ;

Jensen, Lars Juhl .

METHODS, 2015, 74 :83-89

[6] A comprehensive map of molecular drug targets [J].

Santos, Rita ;

Ursu, Oleg ;

Gaulton, Anna ;

Bento, A. Patricia ;

Donadi, Ramesh S. ;

Bologa, Cristian G. ;

Karlsson, Anneli ;

Al-Lazikani, Bissan ;

Hersey, Anne ;

Oprea, Tudor I. ;

Overington, John P. .

NATURE REVIEWS DRUG DISCOVERY, 2017, 16 (01) :19-34

← 1 →