Anti-Methicillin-Resistant S. aureus Activity of Fruiting Body and Mycelial Culture Extracts of Xylaria longipes Nitschke (Ascomycota)

被引：0
作者：
Keekan, K. K. [1 ,2 ,3 ]
Ranadive, K. R. [4 ]
Naik, P. [5 ]
Sendker, J. [6 ]
Padmaraj, S. R. [7 ]
机构：
[1] Yenepoya Deemed Univ, Yenepoya Med Coll, Dept Microbiol, Univ Rd, Mangalore 575018, Karnataka, India
[2] Yenepoya Deemed Univ, Yeneopoya Res Ctr, Univ Rd, Mangalore 575018, Karnataka, India
[3] Univ Coll Dublin, NovaUCD, UCD Res & Innovat, Talam Biotech Ltd, Belfield Innovat Pk,Stillorgan Rd, Dublin D04 V2P1 4, Ireland
[4] PDEAs Annasaheb Magar Mahavidyalaya, Dept Bot, Pune 411028, Maharashtra, India
[5] Mangalore Univ, Dept Biosci, Mangalagangothri 574199, Karnataka, India
[6] Univ Munster, Inst Pharmaceut Biol & Phytochem, Correnstr 48, D-48149 Munster, Germany
[7] Pushpagiri Inst Med Sci & Res Ctr Thiruvalla, Dept Microbiol, Thiruvalla 689101, Kerala, India
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2022年 / 56卷 / 07期
关键词：
antimicrobials; drug resistance; Staphylococcus aureus; wood-rotting fungi; Xylaria longipes; ANTIMICROBIAL ACTIVITY; STAPHYLOCOCCUS-AUREUS; SECONDARY METABOLITES; MUSHROOM; FUNGI; VANCOMYCIN; ACID;
D O I：
10.1007/s11094-022-02733-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Resistance to penicillin by Staphylococcus aureus gave rise to methicillin-resistant S. aureus (MRSA) and the emergence of vancomycin-resistant S. aureus (VRSA) that was reported later. Finding an alternative antimicrobial in the treatment of Staphylococcal infections is the need of the hour. In this context, secondary metabolites of both the fruiting body and mycelia of wood-rotting fungi Xylaria longipes were evaluated for anti-MRSA activity. Thin layer chromatographic (TLC) separation and bioautography of the acetone extract revealed a strong anti-MRSA activity at R-f = 0.69 +/- 0.28. The bioactive anti-MRSA compound was partially characterized by Fourier transform infrared (FTIR) spectroscopy and liquid chromatography-tandem mass spectrometry (LC-MS/MS). The analysis suggested anti-MRSA activity could be due to integric acid, eremoxylarin C, or a related compound.
引用
收藏
页码：958 / 965
页数：8
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