Genetic and molecular targets in lymphoma: implications for prognosis and treatment

被引：4

作者：

Bachegowda, Lohith S. ^{[1
,2
]}

Barta, Stefan K. ^{[3
]}

机构：

[1] Montefiore Med Ctr, Dept Oncol, 110,E 210 St, Bronx, NY 10467 USA

[2] New York Blood Ctr, New York, NY 10065 USA

[3] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

来源：

FUTURE ONCOLOGY | 2014年 / 10卷 / 15期

关键词：

BCL-6; chemokines; ibrutinib; immunomodulatory drugs; ipilimumab; JAK-STAT pathway inhibitors; NF-B; PD-1; B-CELL LYMPHOMA; NON-HODGKIN-LYMPHOMA; PHASE-II TRIAL; NF-KAPPA-B; RITUXIMAB PLUS CYCLOPHOSPHAMIDE; PROTEASOME INHIBITOR BORTEZOMIB; CHRONIC LYMPHOCYTIC-LEUKEMIA; SINGLE-AGENT TEMSIROLIMUS; JAK-STAT PATHWAY; PROTEIN EXPRESSION;

D O I：

10.2217/fon.14.112

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lymphomas are the most common hematologic malignancies with approximately 79,000 new cases estimated for 2013 in the USA. Despite improved outcomes, relapse or recurrence remains a common problem with conventional cytotoxic therapy. Recently, many genetic and molecular mechanisms that drive various cellular events like apoptosis, angiogenesis and cell motility have been more clearly delineated. These new findings, coupled with the advent of high-throughput screening technology have led to the discovery of many compounds that can target specific mutations and/or influence deregulated transcription. In this review, we intend to provide a concise overview of genetic and molecular events that drive cellular processes in lymphomas and represent potential therapeutic targets. Additionally, we briefly discuss the prognostic significance of select biological markers.

引用

页码：2509 / 2528

页数：20

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