Cytokine pattern in very early rheumatoid arthritis favours B-cell activation and survival

被引：49

作者：

Moura, Rita A. ^{[1
]}

Cascao, Rita ^{[1
]}

Perpetuo, Ines ^{[1
]}

Canhao, Helena ^{[1
,2
]}

Vieira-Sousa, Elsa ^{[1
,2
]}

Mourao, Ana F. ^{[1
,3
]}

Rodrigues, Ana M. ^{[1
,2
]}

Polido-Pereira, Joaquim ^{[1
,2
]}

Queiroz, Mario V. ^{[2
]}

Rosario, Henrique S. ^{[4
]}

Souto-Carneiro, Maria M. ^{[5
]}

Graca, Luis ^{[6
,7
]}

Fonseca, Joao E. ^{[1
,2
]}

机构：

[1] Univ Lisbon, Rheumatol Res Unit, Inst Med Mol, Fac Med, P-1649028 Lisbon, Portugal

[2] Hosp Santa Maria, Dept Rheumatol, Ctr Hosp Lisboa Norte, EPE, Lisbon, Portugal

[3] Hosp Egas Moniz, Dept Rheumatol, Ctr Hosp Lisboa Ocidental, EPE, Lisbon, Portugal

[4] Univ Lisbon, Microvasc Biol & Inflammat Unit, Inst Med Mol, Fac Med, P-1649028 Lisbon, Portugal

[5] Autoimmun Grp, Ctr Neurosci & Cell Biol, Coimbra, Portugal

[6] Univ Lisbon, Cellular Immunol Unit, Inst Med Mol, Fac Med, P-1649028 Lisbon, Portugal

[7] Inst Gulbenkian Ciencias, Oeiras, Portugal

来源：

RHEUMATOLOGY | 2011年 / 50卷 / 02期

关键词：

B cells; VERA; Synovial fluid; APRIL; BAFF; BAFF-R; APRIL; TACI;

D O I：

10.1093/rheumatology/keq338

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Methods. A proliferation-inducing ligand (APRIL), B-cell activating factor (BAFF) and IL-21 levels were measured by ELISA in the serum of VERA, other very early arthritis (VEA), established RA patients and controls. SF samples of established RA were also analysed. Results. VERA patients have higher levels of APRIL and BAFF as compared with VEA, established RA and controls. Furthermore, APRIL and BAFF levels are also significantly elevated in RA-SF when compared with serum. Conclusions. The increased levels of APRIL and BAFF in VERA patients suggests that B-cell activation and the development of autoreactive B-cell responses might be crucial in early phases of RA. Therefore, APRIL and BAFF could be promising targets for therapy in the early phase of RA.

引用

页码：278 / 282

页数：5

共 20 条

[1] THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS
ARNETT, FC
EDWORTHY, SM
BLOCH, DA
MCSHANE, DJ
FRIES, JF
COOPER, NS
HEALEY, LA
KAPLAN, SR
LIANG, MH
LUTHRA, HS
MEDSGER, TA
MITCHELL, DM
NEUSTADT, DH
PINALS, RS
SCHALLER, JG
SHARP, JT
WILDER, RL
HUNDER, GG
[J]. ARTHRITIS AND RHEUMATISM, 1988, 31 (03): : 315 - 324
[2] BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells
Badr, Gamal
Borhis, Gwenoline
Lefevre, Eric A.
Chaoul, Nada
Deshayes, Frederique
Dessirier, Valerie
Lapree, Genevieve
Tsapis, Andreas
Richard, Yolande
[J]. BLOOD, 2008, 111 (05) : 2744 - 2754
[3] BARRERA P, 1994, BRIT J RHEUMATOL, V33, P1017
[4] APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells
Belnoue, Elodie
Pihlgren, Maria
McGaha, Tracy L.
Tougne, Chantal
Rochat, Anne-Francoise
Bossen, Claudia
Schneider, Pascal
Huard, Bertrand
Lambert, Paul-Henri
Siegrist, Claire-Anne
[J]. BLOOD, 2008, 111 (05) : 2755 - 2764
[5] TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts
Bossen, Claudia
Cachero, Teresa G.
Tardivel, Aubry
Ingold, Karine
Willen, Laure
Dobles, Max
Scott, Martin L.
Maquelin, Aris
Belnoue, Elodie
Siegrist, Claire-Anne
Chevrier, Stephane
Acha-Orbea, Hans
Leung, Helen
Mackay, Fabienne
Tschopp, Jurg
Schneider, Pascal
[J]. BLOOD, 2008, 111 (03) : 1004 - 1012
[6] TACI and BAFF-R mediate isotype switching in B cells
Castigli, E
Wilson, SA
Scott, S
Dedeoglu, F
Xu, SL
Lam, KP
Bram, RJ
Jabara, H
Geha, RS
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (01) : 35 - 39
[7] Impaired IgA class switching in APRIL-deficient mice
Castigli, E
Scott, S
Dedeoglu, F
Bryce, P
Jabara, H
Bhan, AK
Mizoguchi, E
Geha, RS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (11) : 3903 - 3908
[8] The molecular and cellular basis of corticosteroid resistance
Chikanza, IC
Kozaci, D
Chernajovsky, Y
[J]. JOURNAL OF ENDOCRINOLOGY, 2003, 179 (03) : 301 - 310
[9] Infiltrations of plasma cells in synovium are highly associated with synovial fluid levels of APRIL in inflamed peripheral joints of rheumatoid arthritis
Dong, Weijia
Li, Xiaoyan
Liu, Hui
Zhu, Ping
[J]. RHEUMATOLOGY INTERNATIONAL, 2009, 29 (07) : 801 - 806
[10] Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes
Edwards, JCW
Cambridge, G
[J]. RHEUMATOLOGY, 2001, 40 (02) : 205 - 211

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