Determination of Tropisetron in Human Plasma by Liquid Chromatography Tandem Mass Spectrometry

被引：4

作者：

Sun, Junjie ^{[1
]}

Xu, Yu ^{[1
]}

Jiang, Bo ^{[1
]}

Luo, Yanan ^{[1
]}

Li, Na ^{[1
]}

Guo, Qingxiang ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

来源：

ANALYTICAL LETTERS | 2010年 / 43卷 / 17期

关键词：

Human plasma; Liquid chromatography tandem mass spectrometry; Ondansetron; Pharmacokinetic; Tropisetron; CHEMOTHERAPY-INDUCED NAUSEA; 5-HT3 RECEPTOR ANTAGONISTS; UV DETECTION; ONDANSETRON; PHARMACOKINETICS; METABOLISM; PREVENTION; CYP2D6;

D O I：

10.1080/00032711003763574

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A fast and sensitive liquid chromatography tandem mass spectrometric method has been developed and validated for the determination of tropisetron in human plasma. The HPLC separation was performed on a Phenomenex Synergi Fusion RP80 column using acetonitrile -13mM ammonium acetate - acetic acid (30:70:0.035, v/v) as the isocratic mobile phase. The assay was linear over the concentration range 0.5-128ng/mL. The intra- and inter-assay precision was less than 11.6% for tropisetron. The method was successfully used to characterize the pharmacokinetic profiles of tropisetron in 20 healthy volunteers after an intravenous infusion of 5mg tropisetron.

引用

页码：2672 / 2680

页数：9

共 13 条

[1] Simultaneous determination of ondansetron and tropisetron in human plasma using HPLC with UV detection [J].

Bauer, S ;

Störmer, E ;

Kaiser, R ;

Tremblay, PB ;

Brockmöller, J ;

Roots, I .

BIOMEDICAL CHROMATOGRAPHY, 2002, 16 (03) :187-190

[2] Determination of tropisetron in human plasma by liquid chromatography-tandem mass spectrometry [J].

Deng, Pan ;

Zhong, Dafang ;

Chen, Xiaoyan .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2009, 49 (03) :848-852

[3]

DIXON CM, 1995, DRUG METAB DISPOS, V23, P1225

[4]

FISHER V, 1994, DRUG METAB DISPOS, V22, P269

[5] 5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting -: A comparison of their pharmacology and clinical efficacy [J].

Gregory, RE ;

Ettinger, DS .

DRUGS, 1998, 55 (02) :173-189

[6] Comparative review of 5-HT3 receptor antagonists in the treatment of acute chemotherapy-induced nausea and vomiting [J].

Hesketh, PJ .

CANCER INVESTIGATION, 2000, 18 (02) :163-173

[7] Pharmacokinetics of therapeutic doses of tropisetron in healthy volunteers [J].

Kees, F ;

Färber, L ;

Bucher, M ;

Mair, G ;

Mörike, K ;

Grobecker, H .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2001, 52 (06) :705-707

[8] Effect of the CYP2D6 genotype on the pharmacokinetics of tropisetron in healthy Korean subjects [J].

Kim, MK ;

Cho, JY ;

Lim, HS ;

Hong, KS ;

Chung, JY ;

Bae, KS ;

Oh, DS ;

Shin, SG ;

Lee, SH ;

Lee, DH ;

Min, B ;

Jang, IJ .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2003, 59 (02) :111-116

[9] 5-HT3 receptor antagonists vs traditional agents for the prophylaxis of postoperative nausea and vomiting [J].

Loewen, PS ;

Marra, CA ;

Zed, PJ .

CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 2000, 47 (10) :1008-1018

[10]

Öge A, 2000, J CHEMOTHERAPY, V12, P105

← 1 2 →