Evaluation of urinary miRNA-96 as a potential biomarker for bladder cancer diagnosis

被引：38
|
作者：
Eissa, Sanaa [1 ,2 ]
Habib, Haidy [1 ]
Ali, Esraa [1 ]
Kotb, Yossif [1 ]
机构：
[1] Ain Shams Univ, Fac Med, Dept Med Biochem & Mol Biol, Cairo, Egypt
[2] Ain Shams Fac Med, Oncol Diagnost Unit, Cairo, Egypt
来源：
MEDICAL ONCOLOGY | 2015年 / 32卷 / 01期
关键词：
Bilharziasis; Marker; Real time PCR; Urine cytology; TUMOR-SUPPRESSOR GENE; HEPATOCELLULAR-CARCINOMA; PANCREATIC-CANCER; BREAST-CANCER; MICRORNA; EXPRESSION; PROGNOSIS; CELLS; FOXO1; COST;
D O I：
10.1007/s12032-014-0413-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
For bladder cancer, a new diagnostic marker is needed to avoid painful cystoscopy. The aim of this study was to explore the efficacy of urinary miRNA-96 as molecular marker in bladder cancer diagnosis and its relation to bilharziasis. Urine cytology, serologic assessment of schistosomiasis and estimation of miRNA-96 by real-time PCR were carried out for 94 bladder cancer patients, 30 benign bladder lesions and 60 healthy individuals. Expression of miRNA-96 showed a significant difference among the three tested groups and also between benign and malignant bilharzial cases. Urinary miRNA-96 is a good noninvasive diagnostic biomarker for bladder cancer.
引用
收藏
页码：1 / 7
页数：7
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