Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny

被引：283
作者：
Ara, T
Tokoyoda, K
Sugiyama, T
Egawa, T
Kawabata, K
Nagasawa, T
机构：
[1] Kyoto Univ, Dept Med Syst Control, Inst Frontier Med Sci, Sakyo Ku, Kyoto 6068507, Japan
[2] Osaka Med Ctr Maternal & Child Hlth, Dept Immunol, Osaka 5941101, Japan
来源：
IMMUNITY | 2003年 / 19卷 / 02期
关键词：
D O I：
10.1016/S1074-7613(03)00201-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The physiological role of SDF-1 on hematopoietic stem cells (HSCs) remains elusive. We show that colonization of bone marrow by HSCs in addition to myeloid cells is severely impaired in SDF-1(-/-) embryos by a long-term repopulation assay. Colonization of spleen by HSCs was also affected, but to a lesser extent. Enforced expression of SDF-1 under the control of vascular-specific Tie-2 regulatory sequences could completely rescue the reduction of HSCs but not myeloid cells in SDF-1(-/-) bone marrow. SDF-1 was detected in the vicinity of the vascular endothelial cells in fetal bone marrow. SDF-1 plays a critical role in colonization of bone marrow by HSCs and myeloid cells during ontogeny, and the mechanisms by which SDF-1 functions are distinct between HSCs and myeloid cells.
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收藏
页码：257 / 267
页数：11
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