Mining distinct aldehyde dehydrogenase 1 (ALDH1) isoenzymes in gastric cancer

被引:18
|
作者
Shen, Jia-Xin [1 ]
Liu, Jing [2 ,3 ]
Li, Guan-Wu [4 ]
Huang, Yi-Teng [5 ]
Wu, Hua-Tao [1 ]
机构
[1] Shantou Univ, Dept Gen Surg, Affiliated Hosp 1, Coll Med, Shantou, Peoples R China
[2] Shantou Univ, Chang Jiang Scholars Lab, Coll Med, Shantou, Peoples R China
[3] Shantou Univ, Guangdong Prov Key Lab Diag & Treatment Breast Ca, Canc Hosp, Coll Med, Shantou, Peoples R China
[4] Shantou Univ, Coll Med, Dept Biochem, Open Lab Tumor Mol Biol,Key Lab Mol Biol High Can, Shantou, Peoples R China
[5] Shantou Univ, Hlth Care Ctr, Coll Med, Affiliated Hosp 1, Shantou, Peoples R China
基金
中国国家自然科学基金;
关键词
ALDH1; gastric cancer; prognosis; KM plotter; hazard ratio (HR); STEM-CELLS; POOR-PROGNOSIS; EXPRESSION; MARKER; TUMOR; OVEREXPRESSION; RESISTANCE; CAPACITY; 1A3;
D O I
10.18632/oncotarget.8294
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aldehyde dehydrogenase 1 (ALDH1) consists of a family of intracellular enzymes, highly expressed in stem cells populations of leukemia and some solid tumors. Up to now, 6 isoforms of ALDH1 have been reported. However, the expression patterns and the identity of ALDH1 isoenzymes contributing to ALDH1 activity, as well as the prognostic values of ALDH1 isoenzymes in cancers all remain to be elucidated. Here, we studied the expressions of ALDH1 transcripts in gastric cancer (GC) compared with the normal controls using the ONCOMINE database. Through the Kaplan-Meier plotter database, which contains updated gene expression data and survival information of 876 GC patients, we also investigated the prognostic values of ALDH1 isoenzymes in GC patients. It was found that when compared with normal tissues, ALDH1A1 mRNA expression was downregulated, whereas ALDH1A3 and ALDH1B1 were upregulated in GC patients. In survival analyses, high ALDH1A1 and ALDH1B1 expressions were associated with better overall survival (OS) in all GC patients. In addition, high transcription activity of ALDH1A1 predicted better OS in gastric intestinal type adenocarcinoma, but not in diffuse gastric adenocarcinoma. GC patients with high mRNA level of ALDH1B1 showed better OS in gastric intestinal type, and worse OS in diffuse type. Oppositely, high transcription activities of ALDH1A2, ALDH1A3 and ALDH1L1 predicted worsen overall survival in GC patients, suggesting that these isoenzymes might be responsible mainly for the ALDH1 activities in GC. These data provides ALDH1A2, ALDH1A3 and ALDH1L1 as excellent potential targets for individualized treatment of GC patients.
引用
收藏
页码:25340 / 25349
页数:10
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