Lancifodilactone F:: A novel nortriterpenoid possessing a unique skeleton from Schisandra lancifolia and its anti-HIV activity

被引：54

作者：

Xiao, WL

Li, RT

Li, SH

Li, XL

Sun, HD ^{[1
]}

Zheng, YT

Wang, RR

Lu, Y

Wang, C

Zheng, QT

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China

[2] Chinese Acad Sci, Lab Mol Immunopharmacol, Kunming Inst Zool, Kunming 650223, Yunan, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[4] Chinese Acad Sci, Grad Sch, Beijing 10039, Peoples R China

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 07期

关键词：

D O I：

10.1021/ol0473187

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lancifodilactone F (1), possessing an unprecedented rearranged pentanortriterpenoid backbone derived from cycloartane, was isolated from the leaves and stems of Schisandra lancifolia (Rehd. et Wils) A. C. Smith. Its structure was established by comprehensive NMR and MS spectroscopic analysis, coupled with single-crystal X-ray experiment. Compound 1 exerted minimal cytotoxicity against C8166 cells (CC50 > 200 mu g/mL) and showed anti-HIV activity with EC50 = 20.69 +/- 3.31 mu g/mL and a selectivity index > 6.62.

引用

页码：1263 / 1266

页数：4

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