Synthesis of new derivatives containing pyridine, investigation of MAO inhibitory activities and molecular docking studies

被引：0
|
作者：
Osmaniye, Derya [1 ,2 ]
Saglik, Begum Nurpelin [1 ,2 ]
Levent, Serkan [1 ,2 ]
Ozkay, Yusuf [1 ,2 ]
Kaplancikli, Zafer Asim [1 ]
Turan, Gulhan [1 ]
机构：
[1] Anadolu Univ, Fac Pharm, Dept Pharmaceut Chem, TR-26470 Eskisehir, Turkey
[2] Anadolu Univ, Fac Pharm, Cent Anal Lab, TR-26470 Eskisehir, Turkey
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 2022年 / 77卷 / 11-12期
关键词：
molecular docking; pyridine; selective MAO-B inhibitor; thiazolyl-hydrazone; MONOAMINE-OXIDASE-A; BIOLOGICAL EVALUATION; THIAZOLE DERIVATIVES; RAT-BRAIN; DESIGN; IDENTIFICATION; HYDRAZONE; ALANINE; AMINES;
D O I：
10.1515/znc-2022-0075
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, novel pyridine-containing thiazolyl hydrazone derivatives were synthesized. Structure determinations of the compounds were performed using H-1 NMR, C-13 NMR and HRMS techniques. The biological activities of the compounds were evaluated against MAO enzymes by in vitro fluorometric method. As a result of activity studies, compound 3a showed selective inhibitory activity against MAO-B enzyme with IC50 = 0.088 + 0.003 mu M. The selectivity index of this compound is greater than 1136. Molecular docking studies were carried out using 2V5Z crystal. It has been observed that docking studies and activity studies are in harmony.
引用
收藏
页码：509 / 517
页数：9
相关论文
共 50 条
  • [21] Synthesis, antimicrobial evaluation, and molecular docking studies of new tetrahydrocarbazole derivatives
    Mohamed, Neama A.
    El-Serwy, Walaa S.
    Abd El-Karim, Somaia S.
    Awad, Ghada E. A.
    Elseginy, Samia A.
    RESEARCH ON CHEMICAL INTERMEDIATES, 2016, 42 (02) : 1363 - 1386
  • [22] Benzimidazole derivatives: synthesis, leishmanicidal effectiveness, and molecular docking studies
    Shaukat, Awais
    Mirza, Hira M.
    Ansari, Amna H.
    Yasinzai, Masoom
    Zaidi, Sohail Z.
    Dilshad, Sana
    Ansari, Farzana L.
    MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (08) : 3606 - 3620
  • [23] Synthesis, Molecular Docking and β-Glucuronidase Inhibitory Potential of Indole Base Oxadiazole Derivatives
    Anouar, El Hassane
    Moustapha, Moustapha Eid
    Taha, Muhammad
    Geesi, Mohammed H.
    Farag, Zeinab R.
    Rahim, Fazal
    Almandil, Noor Barak
    Farooq, Rai Khalid
    Nawaz, Muhammad
    Mosaddik, Ashik
    MOLECULES, 2019, 24 (05)
  • [24] Synthesis of flurbiprofen thiadiazole urea derivatives and assessment of biological activities and molecular docking studies
    Kurt, Belma Zengin
    Altundag, Ozlem
    Tokgoz, Merve Nur
    Civelek, Dilek Ozturk
    Tuncay, Fulya Oz
    Cakmak, Ummuhan
    Kolcuoglu, Yakup
    Akdemir, Atilla
    Sonmez, Fatih
    CHEMICAL BIOLOGY & DRUG DESIGN, 2023, 102 (06) : 1458 - 1468
  • [25] Synthesis, antibacterial activities, cytotoxicity, and molecular docking studies of Salicyledene derivatives
    Belay, Yonas
    Muller, Alfred
    Ndinteh, Derek T.
    Kolawole, Oyebamiji A.
    Adeyinka, Adedapo S.
    Fonkui, Thierry Y.
    JOURNAL OF MOLECULAR STRUCTURE, 2023, 1275
  • [26] Synthesis of New Pyrazole Derivatives, Their Anti-Inflammatory and Analgesic Activities, and Molecular Docking Studies
    El Shehry, M. F.
    Ewies, E. F.
    Zayed, E. M.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2019, 89 (03) : 492 - 498
  • [27] Design, synthesis, antimicrobial activity and in silico molecular docking studies of some sulfur containing pyrazole-pyridine hybrids
    Desai, Nisheeth C.
    Jadeja, Dharmpalsinh J.
    Khedkar, Vijay M.
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2022, 197 (12) : 1226 - 1237
  • [28] Synthesis of azachalcones, their α-amylase, α-glucosidase inhibitory activities, kinetics, and molecular docking studies
    Saleem, Faiza
    Kanwal
    Khan, Khalid Mohammed
    Chigurupati, Sridevi
    Solangi, Mehwish
    Nemala, Appala Raju
    Mushtaq, Maria
    Ul-Haq, Zaheer
    Taha, Muhammad
    Perveen, Shahnaz
    BIOORGANIC CHEMISTRY, 2021, 106
  • [29] Synthesis, In Vitro α-Glucosidase Inhibitory Activity and Molecular Docking Studies of Novel Barbituric Acid Derivatives
    Peng, Zhiyun
    Qiu, Jie
    Zhou, Fengjiao
    Cao, Anbai
    Wang, Guangcheng
    LATIN AMERICAN JOURNAL OF PHARMACY, 2018, 37 (01): : 16 - 21
  • [30] Synthesis, Antimicrobial Activity, and Molecular Docking Studies of Aminoguanidine Derivatives Containing an Acylhydrazone Moiety
    Yao, Xiaodong
    Hu, Hongmei
    Wang, Shiben
    Zhao, Wenhao
    Song, Mingxia
    Zhou, Qiugui
    IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2021, 20 (02): : 536 - 545
12345