Translesion synthesis: Y-farnily polymerases and the polymerase switch

被引：302

作者：

Lehmann, Alan R. ^{[1
]}

Niimi, Atsuko

Ogi, Tomoo

Brown, Stephanie

Sabbioneda, Simone

Wing, Jonathan F.

Kannouche, Patricia L.

Green, Catherine M.

机构：

[1] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

[2] Inst Gustave Roussy, CNRS, Lab Genomes & Canc, Villejuif, France

来源：

DNA REPAIR | 2007年 / 6卷 / 07期

基金：

英国医学研究理事会;

关键词：

DNA polymerase; replication factories; PCNA; ubiquitination;

D O I：

10.1016/j.dnarep.2007.02.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the replacement of the replicative polymerase by one of a group of specialised translesion synthesis (TLS) polymerases, most of which belong to the Y-family. Each of these has different substrate specificities for different types of damage. In eukaryotes mono-ubiquitination of PCNA plays a crucial role in the switch from replicative to TLS polymerases at stalled forks. All the Y-family polymerases have ubiquitin binding sites that increase their binding affinity for ubiquitinated PCNA at the sites of stalled forks. (C) 2007 Published by Elsevier B.V.

引用

页码：891 / 899

页数：9

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