Changes in Glycolipid Metabolism During A High-Sucrose Feeding in Spontaneously Diabetic Torii (SDT) Rats, A Genetic Model of Nonobese Type 2 Diabetes

被引：0

作者：

Ohta, Takeshi ^{[1
,2
]}

Miyajima, Katsuhiro ^{[3
]}

Yamada, Takahisa ^{[1
,2
]}

机构：

[1] Niigata Univ, Lab Anim Genet, Grad Sch Sci & Technol, Nishi Ku, Niigata 9502181, Japan

[2] Kyoto Univ, Grad Sch Agr, Lab Anim Breeding & Genet, Sakyo Ku, Kyoto 6068502, Japan

[3] Tokai Univ, Sch Med, Dept Pathol, Isehara, Kanagawa 2591193, Japan

来源：

JOURNAL OF ANIMAL AND VETERINARY ADVANCES | 2010年 / 9卷 / 22期

关键词：

Diabetes; high-sucrose diet; rat; abnormality; fatty liver; serum; DIET; GLUCONEOGENESIS;

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

A high-sucrose diet induces insulin resistance and dyslipidemia in normal rats. The purpose of the present study was to investigate the effects of a high-sucrose diet on glycolipid metabolism in Spontaneously Diabetic Torii (SDT) rats, a genetic model of nonobese type 2 diabetes. Male SDT rats were fed with a high-sucrose (68% of energy) diet from 8-24 weeks of age. SDT rats fed a high-sucrose diet showed hypercholesterolemia, hyperinsulinemia and hyperleptinemia but the body weight and the serum triglyceride level were not increased. Unexpectedly in SDT rats fed a high-sucrose diet, we observed a suppress of the incidence of diabetes mellitus. In computed tomography analysis, SDT rats fed a high-sucrose diet showed an increase of visceral or subcutaneous fat tissue weight. In pathological analyses, slight or mild fatty liver was observed by high-sucrose feeding. A high-sucrose diet in SDT rats induced dyslipidemia, insulin resistance and fat storage but no development of diabetes. High sucrose-fed diabetic rats are considered to be useful for further elucidation of complex mechanisms in glycolipid metabolic abnormality.

引用

页码：2883 / 2889

页数：7

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