Genetic basis of cannabis use: a systematic review

被引：12
作者：
Hillmer, Alannah [1 ]
Chawar, Caroul [1 ]
Sanger, Stephanie [2 ]
D'Elia, Alessia [1 ]
Butt, Mehreen [3 ]
Kapoor, Raveena [4 ]
Kapczinski, Flavio [1 ]
Thabane, Lehana [5 ]
Samaan, Zainab [1 ]
机构：
[1] McMaster Univ, Dept Psychiat & Behav Neurosci, Neurosci Grad Program, 100 West 5th St, Hamilton, ON L8N 3K7, Canada
[2] McMaster Univ, Hlth Sci Lib, 1280 Main St, Hamilton, ON L8S 4L8, Canada
[3] McMaster Univ, Integrated Sci Program, 1280 Main St, Hamilton, ON L8S 4L8, Canada
[4] McMaster Univ, Michael G Degroote Sch Med, 1280 Main St, Hamilton, ON L8S 4L8, Canada
[5] Dept Hlth Res Method Evidence & Impact, 1280 Main St, Hamilton, ON L8S 4L8, Canada
来源：
BMC MEDICAL GENOMICS | 2021年 / 14卷 / 01期
关键词：
Systematic review; Cannabis; Genetics; Genome-wide Association Study; USE DISORDER; MATERNAL STRESS; USE INITIATION; SCHIZOPHRENIA; VOLUMES; IDENTIFICATION; MALNUTRITION; ASSOCIATIONS; METAANALYSIS; BEHAVIOR;
D O I：
10.1186/s12920-021-01035-5
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Background With the increase in cannabis use rates, cannabis use disorder is being reported as one of the most common drug use disorders globally. Cannabis use has several known physical, psychological, and social adverse events, such as altered judgement, poor educational outcomes, and respiratory symptoms. The propensity for taking cannabis and the development of a cannabis use disorder may be genetically influenced for some individuals. Heritability estimates suggest a genetic basis for cannabis use, and several genome-wide association studies (GWASs) have identified possible regions of association, albeit with inconsistent findings. This systematic review aims to summarize the findings from GWASs investigating cannabis use and cannabis use disorder. Methods This systematic review incorporates articles that have performed a GWAS investigating cannabis use or cannabis use disorder. MEDLINE, Web of Science, EMBASE, CINAHL, GWAS Catalog, GWAS Central, and NIH Database of Genotype and Phenotype were searched using a comprehensive search strategy. All studies were screened in duplicate, and the quality of evidence was assessed using the quality of genetic association studies (Q-Genie) tool. All studies underwent qualitative synthesis; however, quantitative analysis was not feasible. Results Our search identified 5984 articles. Six studies met our eligibility criteria and were included in this review. All six studies reported results that met our significance threshold of p <= 1.0 x 10(-7). In total 96 genetic variants were identified. While meta-analysis was not possible, this review identified the following genes, ANKFN1, INTS7, PI4K2B, CSMD1, CST7, ACSS1, and SCN9A, to be associated with cannabis use. These regions were previously reported in different mental health conditions, however not in relation to cannabis use. Conclusion This systematic review summarized GWAS findings within the field of cannabis research. While a meta-analysis was not possible, the summary of findings serves to inform future candidate gene studies and replication efforts. Systematic Review Registration PROSPERO CRD42020176016.
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页数：21
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