A Ga3+ self-assembled fluorescent probe for ATP imaging in vivo

被引:31
|
作者
Xiao, Liangliang [1 ]
Sun, Shiguo [1 ]
Pei, Zhichao [1 ]
Pei, Yuxin [1 ]
Pang, Yi [2 ,3 ]
Xu, Yongqian [1 ]
机构
[1] Northwest A&F Univ, Coll Sci, Yangling 712100, Shaanxi, Peoples R China
[2] Univ Akron, Dept Chem, Akron, OH 44325 USA
[3] Univ Akron, Maurice Morton Inst Polymer Sci, Akron, OH 44325 USA
来源
BIOSENSORS & BIOELECTRONICS | 2015年 / 65卷
基金
中国国家自然科学基金;
关键词
Self-assembly; Fluorescent sensors; Cells imaging; SELECTIVE DETECTION; LUMINESCENT PROBE; ANION RECOGNITION; AQUEOUS-SOLUTION; COORDINATION; ADP; POLYPHOSPHATES; TRIPHOSPHATE; COMPLEXES; CAPSULES;
D O I
10.1016/j.bios.2014.10.038
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Adenosine 5'-triphosphate (ATP) is a functional molecule associated with many important biological processes. Fluorescent detection methods for ATP with facile performance and high selectivity are in demand. One of the possible multi-membered arrays assembled between DHBO and Ga3+ ions was conducted in aqueous solution, which can selectively recognize ATP with fluorescence enhancement from ADP, AMP and other structurally similar nucleoside triphosphates in vitro and in vivo. ATP facilitates the interaction between DHBO and Ga3+ ions, resulting in the fluorescence increase. The detection limit for ATP was calculated to be 5.49 x 10(-7) M, which is much lower than that of intracellular concentrations (1-10 mM). In addition, DHBO-Ga3+ can be applied to detect ATP-relevant enzyme activity. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:166 / 170
页数:5
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