Manufacturing Cell Therapies Using Engineered Biomaterials

被引：33

作者：

Abdeen, Amr A. ^{[1
]}

Saha, Krishanu ^{[1
,2
,3
]}

机构：

[1] Univ Wisconsin, Wisconsin Inst Discovery, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Biomed Engn, Madison, WI 53706 USA

[3] Univ Wisconsin, Dept Med Hist & Bioeth, Madison, WI 53706 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2017年 / 35卷 / 10期

基金：

美国国家科学基金会;

关键词：

PLURIPOTENT STEM-CELLS; EXTRACELLULAR-MATRIX; CLINICAL-TRIALS; DECIPHER CELL; CARDIOMYOCYTES; HETEROGENEITY; CHALLENGES; PLATFORM; CULTURE; DESIGN;

D O I：

10.1016/j.tibtech.2017.06.008

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Emerging manufacturing processes to generate regenerative advanced therapies can involve extensive genomic and/or epigenomic manipulation of autologous or allogeneic cells. These cell engineering processes need to be carefully controlled and standardized to maximize safety and efficacy in clinical trials. Engineered biomaterials with smart and tunable properties offer an intriguing tool to provide or deliver cues to retain stemness, direct differentiation, promote reprogramming, manipulate the genome, or select functional phenotypes. This review discusses the use of engineered biomaterials to control human cell manufacturing. Future work exploiting engineered biomaterials has the potential to generate manufacturing processes that produce standardized cells with well-defined critical quality attributes appropriate for clinical testing.

引用

页码：971 / 982

页数：12

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