The potential role of the EGFR/ERBB2 heterodimer in breast cancer

被引：9
作者：
Cicenas, Jonas [1 ]
机构：
[1] Univ Bern, Div Clin Immunol, Dept Vet Clin Med, CH-3001 Bern, Switzerland
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 2007年 / 17卷 / 06期
关键词：
breast cancer; epidermal growth factor receptor; ErbB2; tyrosine kinase inhibitors;
D O I：
10.1517/13543776.17.6.607
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Epidermal growth factor receptor (EGFR) and ErbB2 are the best-characterised members of the ErbB family of receptor tyrosine kinases. Both receptors are frequently deregulated in human cancers and both are targets for anticancer drugs. ErbB2 amplification and overexpression are associated with a poor prognosis in breast cancer patients. Over the last decade, evidence has revealed that ErbB2 interacts with EGFR in order to achieve its full oncogenic potential. Therefore, assessment of EGFR and ErbB2 coexpression can potentially predict the outcome of the disease as well as success of therapies better than the assessment of single receptors. Moreover, it is not single-agent therapies, targeting one receptor, but combinations or several receptor-targeted therapies that may be the best way to fight cancer.
引用
收藏
页码：607 / 616
页数：10
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