Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 Viruses

被引：5

作者：

Zhang, Hongbo ^{[1
,2
]}

Yao, Yanfeng ^{[1
]}

Li, Yan ^{[1
]}

Chen, Jianjun ^{[1
]}

Chen, Ze ^{[1
]}

机构：

[1] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China

[2] Louisiana State Univ Hlth Sci Ctr, Shreveport, LA USA

来源：

FRONTIERS IN MICROBIOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

Dongting Lake; water-borne; genotyping; phylogenetic analysis; MOLECULAR-BASIS; REPLICATION; VIRULENCE; EVOLUTION;

D O I：

10.3389/fmicb.2022.896469

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this study, we isolated 10 H5N1 strains from water samples in Dongting Lake and 4 H5N1 strains from lakeside backyard poultry. These isolates belonged to three distinct clades (clade 2.3.2, 2.3.4, and 7). Phylogenetic analysis showed a diversified genome constellation. The genetic characteristics of some viruses isolated from water samples were extremely similar to those from lakeside poultry. Pathogenic experiments showed that selected represented isolates in this study were highly pathogenic for SPF chickens but had a diversified virulence in mice. The results of our study suggested the potential transmission of avian influenza (H5N1) between the poultry and wild waterfowls and water body around the habitat may play an important role.

引用

页数：5

共 17 条

[1]

[Anonymous], 2018, Cumulative number of confirmed human cases of avian influenza A(H5N1) reported to WHO

[2] Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus [J].

Claas, ECJ ;

Osterhaus, ADME ;

van Beek, R ;

De Jong, JC ;

Rimmelzwaan, GF ;

Senne, DA ;

Krauss, S ;

Shortridge, KF ;

Webster, RG .

LANCET, 1998, 351 (9101) :472-477

[3] X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs [J].

Ha, Y ;

Stevens, DJ ;

Skehel, JJ ;

Wiley, DC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (20) :11181-11186

[4] Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses [J].

Hatta, M ;

Gao, P ;

Halfmann, P ;

Kawaoka, Y .

SCIENCE, 2001, 293 (5536) :1840-1842

[5] Universal primer set for the full-length amplification of all influenza A viruses [J].

Hoffmann, E ;

Stech, J ;

Guan, Y ;

Webster, RG ;

Perez, DR .

ARCHIVES OF VIROLOGY, 2001, 146 (12) :2275-2289

[6] PERPETUATION OF INFLUENZA-A VIRUSES IN ALASKAN WATERFOWL RESERVOIRS [J].

ITO, T ;

OKAZAKI, K ;

KAWAOKA, Y ;

TAKADA, A ;

WEBSTER, RG ;

KIDA, H .

ARCHIVES OF VIROLOGY, 1995, 140 (07) :1163-1172

[7] Detection and isolation of H5N1 influenza virus from large volumes of natural water [J].

Khalenkov, Alexey ;

Laver, W. Graeme ;

Webster, Robert G. .

JOURNAL OF VIROLOGICAL METHODS, 2008, 149 (01) :180-183

[8] Reliable universal RT-PCR assays for studying influenza polymerase subunit gene sequences from all 16 haemagglutinin subtypes [J].

Li, Olive T. W. ;

Barr, Ian ;

Leung, Connie Y. H. ;

Chen, Honglin ;

Guan, Yi ;

Peiris, J. S. Malik ;

Poon, Leo L. M. .

JOURNAL OF VIROLOGICAL METHODS, 2007, 142 (1-2) :218-222

[9] Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model [J].

Li, ZJ ;

Chen, HL ;

Jiao, PR ;

Deng, GH ;

Tian, GB ;

Li, YB ;

Hoffmann, E ;

Webster, RG ;

Matsuoka, Y ;

Yu, KZ .

JOURNAL OF VIROLOGY, 2005, 79 (18) :12058-12064

[10] Virulence of H5N1 avian influenza virus enhanced by a 15-nucleotide deletion in the viral nonstructural gene [J].

Long, Jin-Xue ;

Peng, Da-Xin ;

Liu, Yu-Liang ;

Wu, Yan-Tao ;

Liu, Xiu-Fan .

VIRUS GENES, 2008, 36 (03) :471-478

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