Nicotine Addiction

被引：1047
作者：
Benowitz, Neal L. [1 ,2 ,3 ]
机构：
[1] San Francisco Gen Hosp, Med Ctr, Med Serv, Div Clin Pharmacol & Expt Therapeut, San Francisco, CA 94110 USA
[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2010年 / 362卷 / 24期
关键词：
GENOME-WIDE ASSOCIATION; BRAIN REWARD SYSTEMS; CIGARETTE-SMOKING; ACETYLCHOLINE-RECEPTOR; LUNG-CANCER; PSYCHIATRIC-DISORDERS; SUSCEPTIBILITY LOCUS; TOBACCO WITHDRAWAL; MONOAMINE-OXIDASE; SEX-DIFFERENCES;
D O I：
10.1056/NEJMra0809890
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This review gives an account of the cigarette as a highly efficient nicotine delivery system. It explains how nicotine induces pleasure, reduces stress and anxiety, and causes addiction to tobacco smoking. The basis of nicotine addiction rests on its effects on the brain, but addiction is also influenced by learned or conditioned factors, genetics, and social and environmental conditions. Copyright © 2010 Massachusetts Medical Society. All rights reserved.
引用
收藏
页码：2295 / 2303
页数：9
相关论文
共 80 条
  • [51] Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence
    Malaiyandi, V
    Sellers, EM
    Tyndale, RF
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2005, 77 (03) : 145 - 158
  • [52] Long-term potentiation of excitatory inputs to brain reward areas by nicotine
    Mansvelder, HD
    McGehee, DS
    [J]. NEURON, 2000, 27 (02) : 349 - 357
  • [53] Cellular and synaptic mechanisms of nicotine addiction
    Mansvelder, HD
    McGehee, DS
    [J]. JOURNAL OF NEUROBIOLOGY, 2002, 53 (04): : 606 - 617
  • [54] Schizophrenia and the α7 nicotinic acetylcholine receptor
    Martin, Laura F.
    Freedman, Robert
    [J]. INTEGRATING THE NEUROBIOLOGY OF SCHIZOPHRENIA, 2007, 78 : 225 - 246
  • [55] Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors
    Maskos, U
    Molles, BE
    Pons, S
    Besson, M
    Guiard, BP
    Guilloux, JP
    Evrard, A
    Cazala, P
    Cormier, A
    Mameli-Engvall, M
    Dufour, N
    Cloëz-Tayarani, I
    Bemelmans, AP
    Mallet, J
    Gardier, AM
    David, V
    Faure, P
    Granon, S
    Changeux, JP
    [J]. NATURE, 2005, 436 (7047) : 103 - 107
  • [56] Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction
    Mineur, Yann S.
    Picciotto, Marina R.
    [J]. BIOCHEMICAL PHARMACOLOGY, 2008, 75 (01) : 323 - 333
  • [57] Damage to the insula disrupts addiction to cigarette smoking
    Naqvi, Nasir H.
    Rudrauf, David
    Damasio, Hanna
    Bechara, Antoine
    [J]. SCIENCE, 2007, 315 (5811) : 531 - 534
  • [58] Is there a common molecular pathway for addiction?
    Nestler, EJ
    [J]. NATURE NEUROSCIENCE, 2005, 8 (11) : 1445 - 1449
  • [59] Repeated nicotine exposure enhances responding with conditioned reinforcement
    Olausson, P
    Jentsch, JD
    Taylor, JR
    [J]. PSYCHOPHARMACOLOGY, 2004, 173 (1-2) : 98 - 104
  • [60] Sex differences in the subjective and reinforcing effects of cigarette nicotine dose
    Perkins, KA
    Jacobs, L
    Sanders, M
    Caggiula, AR
    [J]. PSYCHOPHARMACOLOGY, 2002, 163 (02) : 194 - 201
12345678