Association between frontal cortico-limbic white-matter microstructure and risk for pediatric depression

被引：9

作者：

Uchida, Mai ^{[1
,2
]}

Hung, Yuwen ^{[3
,4
]}

Green, Allison ^{[1
]}

Kelberman, Caroline ^{[1
]}

Capella, James ^{[3
,4
]}

Gaillard, Schuylar L. ^{[3
,4
]}

Gabrieli, John D. E. ^{[3
,4
]}

Biederman, Joseph ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Clin & Res Programs Pediat Psychopharmacol & Adul, Boston, MA 02114 USA

[2] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA

[3] MIT, Dept Brain & Cognit Sci, MIT Integrated Learning Initiat, E25-618, Cambridge, MA 02139 USA

[4] MIT, McGovern Inst Brain Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2021年 / 318卷

基金：

加拿大健康研究院;

关键词：

Pediatric depression; Major depressive disorder; Emotional dysregulation; Bipolar disorder; Diffusion tensor imaging; White matter; Child behavior checklist; BIPOLAR DISORDER; FAMILIAL RISK; DYSREGULATION PROFILE; MAJOR DEPRESSION; DIFFUSION; CHILDREN; ACTIVATION; PREDICTS; MOTION; YOUTH;

D O I：

10.1016/j.pscychresns.2021.111396

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study aimed to identify white-matter microstructural characteristics associated with risk for pediatric major depressive disorder (MDD) measured by the Child Behavior Checklist (CBCL) Anxiety/Depression scores. Children (N = 32) of both sexes, aged 6-12, underwent T1-weighted whole-head anatomical and diffusion-weighted imaging. Each participant's mean diffusion measure image was generated and thinned to create an alignmentinvariant tract representation. Voxel-wise analysis on the resulting map was carried out in Track Based Spatial Statistics (TBSS) using general linear models by regressing the CBCL-Anxiety/Depression score against measures of diffusion tensor imaging (DTI). We also compared these results with prior DTI findings from the same children associated with CBCL-Emotion Dysregulation profile, an indicator for bipolar disorder. TBSS voxel-wise analysis showed a significant negative correlation between fractional anisotropy (FA) and CBCL-Anxiety/Depression scores localized in the right anterior cingulum and connected corpus callosal region. The negative FA correlations in these regions were greater in CBCL-Anxiety/ Depression scores compared to CBCL-Emotional Dysregulation scores. Reduced white-matter connectivity in the anterior cingulum and connected corpus callosal region may represent a biomarker of risk for pediatric MDD. These results may help identify brain differences associated with the development of MDD, and assist with earlier clinical identification of pediatric MDD.

引用

页数：8

共 53 条

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