C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging

被引:4
作者
Acampa, Wanda [2 ,3 ]
Di Taranto, Maria D. [4 ]
Morgante, Alberto [1 ,5 ]
Salvatore, Barbara [2 ,3 ,4 ]
Evangelista, Laura [2 ,3 ]
Ricci, Francesca [2 ,3 ]
Costanzo, Pierluigi [6 ]
De Sisto, Emma [1 ]
Filardi, Pasquale P. [6 ]
Petretta, Mario [6 ]
Fortunato, Giuliana [1 ,5 ]
Cuocolo, Alberto [2 ,3 ,4 ]
机构
[1] Univ Naples Federico II, Dept Biochem & Med Biotechnol, I-80131 Naples, Italy
[2] Univ Naples Federico II, Dipartimento Sci Biomorfol & Funzionali, I-80131 Naples, Italy
[3] CNR, Ist Biostrutture & Bioimmagini, Naples, Italy
[4] Fdn IRCCS SDN, Naples, Italy
[5] CEINGE Biotecnol Avanzate SCa Rl, Naples, Italy
[6] Univ Naples Federico II, Dipartimento Med Clin Sci Cardiovasc & Immunol, I-80131 Naples, Italy
关键词
Inflammation; myocardial ischemia; single nucleotide polymorphisms; paraoxonase; C-reactive protein; MYOCARDIAL-PERFUSION SPECT; CORONARY-ARTERY-DISEASE; HIGH-DENSITY-LIPOPROTEIN; STABLE ANGINA-PECTORIS; GENE POLYMORPHISMS; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; HEART-DISEASE; RISK; ATHEROSCLEROSIS;
D O I
10.3109/00365513.2010.548529
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background. Oxidation and inflammation are linked processes playing an important role in the development and progression of coronary artery disease (CAD). The relation between oxidation and inflammation markers with myocardial ischemia is still controversial. We assessed the association between paraoxonase (PON) polymorphisms (rs854560, rs662, rs7493) and high sensitivity C-reactive protein levels with stress-induced ischemia in patients with suspected CAD. Materials and methods. Patients (n = 203; 78 men; mean age 59 +/- 10 years), with suspected CAD underwent on the same day stress/rest Tc-99m sestamibi cardiac single-photon emission computed tomography and venous blood samples collection, to assess PON polymorphisms, lipid profile and high sensitivity C-reactive protein levels. Results. At cardiac tomography, 43 (21%) patients had stress-induced myocardial ischemia and 160 (79%) did not. At logistic regression analysis, diabetes (p < 0.005), sex (p = 0.020) and high-density lipoprotein (HDL)-cholesterol levels (p < 0.050) were independently associated with stress-induced ischemia. No differences of PON1 and PON2 genotype frequencies were observed between patients with and without stress-induced ischemia. Multiple linear regression analysis showed that LL genotype for PON1 (p < 0.03), high body mass index (BMI) values (p < 0.001) and low HDL-cholesterol levels (p < 0.05) are associated with high C-reactive protein levels independently from presence of stress-induced ischemia, age, sex, diabetes, hypertension, statin therapy, smoking and total cholesterol levels. Conclusions. The results of this study identified a weak association between the M55L polymorphism in PON1 gene and C-reactive protein levels. BMI showed a major role in the determination of C-reactive protein levels. No association between PON polymorphisms and stress-induced ischemia was found.
引用
收藏
页码:179 / 184
页数:6
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