Are all stem cells equal? Systematic review, evidence map, and meta-analyses of preclinical stem cell-based therapies for bronchopulmonary dysplasia

被引:31
作者
Augustine, Sajit [1 ,2 ]
Cheng, Wei [3 ]
Avey, Marc T. [4 ]
Chan, Monica L. [5 ]
Lingappa, Srinivasa Murthy Chitra [5 ]
Hutton, Brian [3 ,6 ]
Thebaud, Bernard [3 ,5 ,7 ]
机构
[1] Windsor Reg Hosp, Div Neonatol, 1995 Lens Ave, Windsor, ON N8W 1L9, Canada
[2] Western Univ, Dept Pediat, Schulich Med & Dent, London, ON, Canada
[3] Ottawa Hosp Res Inst, Ottawa, ON, Canada
[4] ICF Canada, Ottawa, ON, Canada
[5] Childrens Hosp Eastern Ontario, Dept Neonatol, Ottawa, ON, Canada
[6] Univ Ottawa, Fac Med, Sch Epidemiol Publ Hlth & Prevent Med, Ottawa, ON, Canada
[7] Univ Ottawa, Childrens Hosp Eastern Ontario, Dept Pediat, Res Inst, Ottawa, ON, Canada
关键词
animal model; bronchopulmonary dysplasia; cell-based therapy; lung injury; network meta-analysis; preclinical; preterm birth; stem cells; systematic review; translation; INDUCED LUNG INJURY; LOW-BIRTH-WEIGHT; LONG-TERM; PROGENITOR CELLS; ANIMAL-MODELS; INTRATRACHEAL TRANSPLANTATION; NEONATAL HYPEROXIA; VASCULAR STRUCTURE; MURINE MODEL; ALVEOLAR;
D O I
10.1002/sctm.19-0193
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Regenerative stem cell-based therapies for bronchopulmonary dysplasia (BPD), the most common preterm birth complication, demonstrate promise in animals. Failure to objectively appraise available preclinical data and identify knowledge gaps could jeopardize clinical translation. We performed a systematic review and network meta-analysis (NMA) of preclinical studies testing cell-based therapies in experimental neonatal lung injury. Fifty-three studies assessing 15 different cell-based therapies were identified: 35 studied the effects of mesenchymal stromal cells (MSCs) almost exclusively in hyperoxic rodent models of BPD. Exploratory NMAs, for select outcomes, suggest that MSCs are the most effective therapy. Although a broad range of promising cell-based therapies has been assessed, few head-to-head comparisons and unclear risk of bias exists. Successful clinical translation of cell-based therapies demands robust preclinical experimental design with appropriately blinded, randomized, and statistically powered studies, based on biological plausibility for a given cell product, in standardized models and endpoints with transparent reporting.
引用
收藏
页码:158 / 168
页数:11
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