Regulatory roles of transforming growth factor beta family members in folliculogenesis

被引：32

作者：

Myers, Michelle ^{[1
]}

Pangas, Stephanie A. ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA

来源：

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE | 2010年 / 2卷 / 01期

关键词：

BONE MORPHOGENETIC PROTEIN-15; OVARIAN FOLLICULAR DEVELOPMENT; INCREASED OVULATION RATE; TUMOR-SUPPRESSOR GENE; DIFFERENTIATION FACTOR-9; SUPERFAMILY MEMBERS; SYNERGISTIC ROLES; BMP15; CELLS; GDF9;

D O I：

10.1002/wsbm.21

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Bidirectional signaling between the oocyte and surrounding somatic cells is absolutely essential for successful germ cell development in mammals. Oocytes secrete proteins that are necessary for granulosa cells growth and differentiation, whilst granulosa cells regulate oocyte development and integrate ovarian function with the rest of the body by orchestrating gonadal steroidogenesis. The importance of communication between the oocyte and granulosa cells is highlighted by genetic deletion of members of the transforming growth factor beta (TGF beta) family and their downstream signaling components. Such knockout models have uncovered an interesting spectrum of reproductive phenotypes that have greatly advanced our knowledge of ovarian function and dysfunction. The current review focuses on some of the more recent transgenic mouse models that elucidate the intraovarian TGF beta signaling vital for oocyte and granulosa cell development. (C) 2009 John Wiley & Sons, Inc. WIREs Syst Biol Med 2010 2 117-125

引用

页码：117 / 125

页数：9

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