Adult Stem Cells for Bone Regeneration and Repair

被引：183
作者：
Iaquinta, Maria Rosa [1 ]
Mazzoni, Elisa [1 ]
Bononi, Ilaria [1 ]
Rotondo, John Charles [1 ]
Mazziotta, Chiara [1 ]
Montesi, Monica [2 ]
Sprio, Simone [2 ]
Tampieri, Anna [2 ]
Tognon, Mauro [1 ]
Martini, Fernanda [1 ]
机构：
[1] Univ Ferrara, Dept Morphol Surg & Expt Med, Ferrara, Italy
[2] CNR, Inst Sci & Technol Ceram, Faenza, Italy
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2019年 / 7卷
关键词：
stem cell; regenerative medicine; differentiation; bone; repair; CALCIUM-PHOSPHATE CEMENT; UMBILICAL-CORD BLOOD; HUMAN AMNIOTIC-FLUID; OSTEOGENIC DIFFERENTIATION; EXTRACELLULAR-MATRIX; TRABECULAR BONE; STROMAL CELLS; ADIPOSE-TISSUE; IN-VITRO; MARROW;
D O I：
10.3389/fcell.2019.00268
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The regeneration of bone fractures, resulting from trauma, osteoporosis or tumors, is a major problem in our super-aging society. Bone regeneration is one of the main topics of concern in regenerative medicine. In recent years, stem cells have been employed in regenerative medicine with interesting results due to their self-renewal and differentiation capacity. Moreover, stem cells are able to secrete bioactive molecules and regulate the behavior of other cells in different host tissues. Bone regeneration process may improve effectively and rapidly when stem cells are used. To this purpose, stem cells are often employed with biomaterials/scaffolds and growth factors to accelerate bone healing at the fracture site. Briefly, this review will describe bone structure and the osteogenic differentiation of stem cells. In addition, the role of mesenchymal stem cells for bone repair/regrowth in the tissue engineering field and their recent progress in clinical applications will be discussed.
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页数：15
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共 176 条
[1]   Platelet-rich plasma incorporated electrospun PVA-chitosan-HA nanofibers accelerates osteogenic differentiation and bone reconstruction [J].
Abazari, Mohammad Foad ;
Nejati, Fatemeh ;
Nasiri, Navid ;
Khazeni, Zahra Al Sadat ;
Nazari, Bahareh ;
Enderami, Seyed Ehsan ;
Mohajerani, Hassan .
GENE, 2019, 720
[2]   Enhanced mesenchymal stromal cell recruitment via natural killer cells by incorporation of inflammatory signals in biomaterials [J].
Almeida, Catarina R. ;
Vasconcelos, Daniela P. ;
Goncalves, Raquel M. ;
Barbosa, Mario A. .
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2012, 9 (67) :261-271
[3]   Mesenchymal stem cells: immune evasive, not immune privileged [J].
Ankrum, James A. ;
Ong, Joon Faii ;
Karp, Jeffrey M. .
NATURE BIOTECHNOLOGY, 2014, 32 (03) :252-260
[4]   Mesenchymal stem cells for the management of rheumatoid arthritis: immune modulation, repair or both? [J].
Ansboro, Sharon ;
Roelofs, Anke J. ;
De Bari, Cosimo .
CURRENT OPINION IN RHEUMATOLOGY, 2017, 29 (02) :201-207
[5]   Bone regeneration and stem cells [J].
Arvidson, K. ;
Abdallah, B. M. ;
Applegate, L. A. ;
Baldini, N. ;
Cenni, E. ;
Gomez-Barrena, E. ;
Granchi, D. ;
Kassem, M. ;
Konttinen, Y. T. ;
Mustafa, K. ;
Pioletti, D. P. ;
Sillat, T. ;
Finne-Wistrand, A. .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2011, 15 (04) :718-746
[6]   Reprint of: Extracellular matrix as a biological scaffold material: Structure and function [J].
Badylak, Stephen F. ;
Freytes, Donald O. ;
Gilbert, Thomas W. .
Acta Biomaterialia, 2015, 23 (0S)
[7]   New hydroxyapatite nanophases with enhanced osteogenic and anti-bacterial activity [J].
Ballardini, A. ;
Montesi, M. ;
Panseri, S. ;
Vandini, A. ;
Balboni, P. G. ;
Tampieri, A. ;
Sprio, S. .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2018, 106 (02) :521-530
[8]   Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue [J].
Bayraktar, HH ;
Morgan, EF ;
Niebur, GL ;
Morris, GE ;
Wong, EK ;
Keaveny, TM .
JOURNAL OF BIOMECHANICS, 2004, 37 (01) :27-35
[9]   Impact of Aging on the Regenerative Properties of Bone Marrow-, Muscle-, and Adipose-Derived Mesenchymal Stem/Stromal Cells [J].
Beane, Olivia S. ;
Fonseca, Vera C. ;
Cooper, Leroy L. ;
Koren, Gideon ;
Darling, Eric M. .
PLOS ONE, 2014, 9 (12)
[10]   Tissue-derived mesenchymal stromal cells used as vehicles for anti-tumor therapy exert different in vivo effects on migration capacity and tumor growth [J].
Belmar-Lopez, Carolina ;
Mendoza, Gracia ;
Oberg, Daniel ;
Burnet, Jerome ;
Simon, Carlos ;
Cervello, Irene ;
Iglesias, Maite ;
Carlos Ramirez, Juan ;
Lopez-Larrubia, Pilar ;
Quintanilla, Miguel ;
Martin-Duque, Pilar .
BMC MEDICINE, 2013, 11
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